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神经肌肉电刺激和饮食干预减轻继发进展型多发性硬化症患者氧化应激并显著改善功能:一例报告

Neuromuscular electrical stimulation and dietary interventions to reduce oxidative stress in a secondary progressive multiple sclerosis patient leads to marked gains in function: a case report.

作者信息

Reese David, Shivapour Ezzatolah T, Wahls Terry L, Dudley-Javoroski Shauna D, Shields Richard

机构信息

Performance Therapies, PC, Ridgeway Drive, Coralville, Iowa, USA.

出版信息

Cases J. 2009 Aug 10;2:7601. doi: 10.4076/1757-1626-2-7601.

DOI:10.4076/1757-1626-2-7601
PMID:19918474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2769364/
Abstract

Neuromuscular electrical stimulation has been used to aid musculoskeletal recovery. Excessive oxidative stress and excitoxicity are implicated in secondary progressive multiple sclerosis. A 52-year-old white female with SPMS had been scooter- and cane-dependent for 4 years. She requested and received a trial of neuromuscular electrical stimulation. Two months after initiating NMES the patient adopted several nutritional interventions to lower oxidative stress and excito-toxicity. During the first 2 months of neuromuscular electrical stimulation, the therapist observed modest gait improvements. Following the addition of nutritional interventions, more rapids gains in strength and endurance, including muscle groups not receiving neuromuscular electrical stimulation were observed by both the therapist and the patient. After 8 months of neuromuscular electrical stimulation (6 months of nutritional intervention) the patient's function had improved sufficiently that she no longer used a scooter or cane and rode her bicycle routinely 8 miles, including hills.

摘要

神经肌肉电刺激已被用于辅助肌肉骨骼恢复。过度的氧化应激和兴奋性毒性与继发进展型多发性硬化症有关。一名52岁的白人女性,患有继发进展型多发性硬化症,依靠踏板车和拐杖行动已有4年。她请求并接受了神经肌肉电刺激试验。开始进行神经肌肉电刺激两个月后,患者采取了几种营养干预措施以降低氧化应激和兴奋性毒性。在神经肌肉电刺激的前两个月,治疗师观察到患者步态有适度改善。在增加营养干预措施后,治疗师和患者都观察到力量和耐力有更快的提升,包括未接受神经肌肉电刺激的肌肉群。经过8个月的神经肌肉电刺激(6个月的营养干预),患者的功能有了足够的改善,她不再使用踏板车或拐杖,并且经常骑自行车行驶8英里,包括爬坡路段。

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J Neuroimmunol. 2008 Sep 15;201-202:200-11. doi: 10.1016/j.jneuroim.2008.05.034. Epub 2008 Jul 30.
2
Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis.在进行性多发性硬化症小鼠模型中轴突损失和残疾的逆转
J Clin Invest. 2008 Apr;118(4):1532-43. doi: 10.1172/JCI33464.
3
Altered glutamate reuptake in relapsing-remitting and secondary progressive multiple sclerosis cortex: correlation with microglia infiltration, demyelination, and neuronal and synaptic damage.复发缓解型和继发进展型多发性硬化症皮质中谷氨酸再摄取的改变:与小胶质细胞浸润、脱髓鞘以及神经元和突触损伤的相关性。
J Neuropathol Exp Neurol. 2007 Aug;66(8):732-9. doi: 10.1097/nen.0b013e31812571b0.
4
Oxidative stress and excitotoxicity: a therapeutic issue in multiple sclerosis?氧化应激与兴奋毒性:多发性硬化症中的一个治疗问题?
Mult Scler. 2008 Jan;14(1):22-34. doi: 10.1177/1352458507080111. Epub 2007 Sep 19.
5
Validation of the NARCOMS registry: diagnosis.NARCOMS注册库的验证:诊断
Mult Scler. 2007 Jul;13(6):770-5. doi: 10.1177/1352458506075031. Epub 2007 Mar 15.
6
Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis.线粒体氧化应激的抑制在实验性视神经炎中提供长期神经保护作用。
Invest Ophthalmol Vis Sci. 2007 Feb;48(2):681-91. doi: 10.1167/iovs.06-0553.
7
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Stroke. 2006 Jan;37(1):172-8. doi: 10.1161/01.STR.0000195129.95220.77. Epub 2005 Dec 1.
8
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