2004-2007 年西班牙人型和牛型分枝杆菌引起的结核病。

Human tuberculosis due to Mycobacterium bovis and M. caprae in Spain, 2004-2007.

机构信息

National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain.

出版信息

Int J Tuberc Lung Dis. 2009 Dec;13(12):1536-41.

PMID:19919773

Abstract

OBJECTIVE

To identify the characteristics associated with human tuberculosis (TB) caused by Mycobacterium bovis and M. caprae in Spain.

DESIGN

Retrospective study covering all M. bovis and M. caprae isolates identified at the National Mycobacterial Reference Laboratory (NRL) from 2004 to 2007. We studied the microbiological and epidemiological characteristics of patients and performed a genetic analysis of isolates.

RESULTS

The study covered 110 isolates (89 M. bovis and 21 M. caprae) that accounted for respectively 1.9% and 0.3% of the M. tuberculosis complex isolates available at the NRL. Data on risk of exposure to M. bovis or to M. caprae were available in 82 (74%) of the 110 cases, with 60 (73%) registering a probable or possible risk of exposure and 22 (27%) registering no risk. Probable exposure mainly included crop and livestock farmers, and possible exposure included patients born in countries with a high prevalence of bovine TB. Spoligotyping of strains yielded 36 different patterns, with SB0121, SB0134 and SB0157 being predominant.

CONCLUSIONS

In Spain, cases of human TB due to M. bovis and M. caprae represent a small proportion of all TB cases, and for a high percentage of cases this is linked to occupational exposure and coming from countries endemic for bovine TB.

摘要

目的

确定与西班牙的牛分枝杆菌和山羊分枝杆菌引起的人类肺结核（TB）相关的特征。

设计

回顾性研究，涵盖了 2004 年至 2007 年国家分枝杆菌参考实验室（NRL）鉴定的所有牛分枝杆菌和山羊分枝杆菌分离株。我们研究了患者的微生物学和流行病学特征，并对分离株进行了遗传分析。

结果

研究涵盖了 110 株分离株（89 株牛分枝杆菌和 21 株山羊分枝杆菌），分别占 NRL 提供的结核分枝杆菌复合体分离株的 1.9%和 0.3%。在 110 例病例中，有 82 例（74%）有牛分枝杆菌或山羊分枝杆菌暴露风险的数据，其中 60 例（73%）有确定或可能的暴露风险，22 例（27%）无风险。可能的暴露主要包括作物和牲畜农民，而可能的暴露则包括来自牛型结核流行国家的患者。菌株 spoligotyping 产生了 36 种不同的模式，SB0121、SB0134 和 SB0157 占主导地位。