Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA.
Bioinformatics. 2012 Aug 15;28(16):2209-10. doi: 10.1093/bioinformatics/bts366. Epub 2012 Jun 27.
We introduce GO-Elite, a flexible and powerful pathway analysis tool for a wide array of species, identifiers (IDs), pathways, ontologies and gene sets. In addition to the Gene Ontology (GO), GO-Elite allows the user to perform over-representation analysis on any structured ontology annotations, pathway database or biological IDs (e.g. gene, protein or metabolite). GO-Elite exploits the structured nature of biological ontologies to report a minimal set of non-overlapping terms. The results can be visualized on WikiPathways or as networks. Built-in support is provided for over 60 species and 50 ID systems, covering gene, disease and phenotype ontologies, multiple pathway databases, biomarkers, and transcription factor and microRNA targets. GO-Elite is available as a web interface, GenMAPP-CS plugin and as a cross-platform application.
我们介绍 GO-Elite，这是一个灵活且强大的通路分析工具，适用于众多物种、标识符（ID）、通路、本体和基因集。除了基因本体论（GO）之外，GO-Elite 还允许用户对任何结构化的本体注释、通路数据库或生物 ID（例如基因、蛋白质或代谢物）进行过度表达分析。GO-Elite 利用生物本体的结构化性质来报告一组最小的非重叠术语。结果可以在 WikiPathways 上可视化，也可以作为网络可视化。该工具内置支持超过 60 个物种和 50 个 ID 系统，涵盖基因、疾病和表型本体、多个通路数据库、生物标志物以及转录因子和 microRNA 靶标。GO-Elite 可作为网络界面、GenMAPP-CS 插件以及跨平台应用程序使用。
