Department of Clinical Engineering, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom.
Retina. 2010 Feb;30(2):300-4. doi: 10.1097/IAE.0b013e3181babe0c.
The purpose was to study the emulsification of silicone oil tamponade agents that cause clinical complications. This study aimed to increase the emulsification resistance of silicone oil 1,000 to be at least as resistant as silicone oil 5,000 while maintaining the shear viscosity <5,000 mPa/s to aid injection and removal.
High-molecular-weight (423 kDa) poly(dimethyl siloxane) was added to silicone oil 1,000 at 5% and 10% w/w concentration. The shear and extensional viscosity of 1,000 and 5,000, a 50:50 mixture of 1,000 and 5,000 and 5% and 10% w/w additive blends, respectively, of silicone oil were measured using capillary breakup extensional, rotational shear, and capillary extrusion rheometry. In vitro emulsification was assessed qualitatively after agitation using Pluronic F68 or a protein solution as the emulsion stabilizer.
The addition of high-molecular-weight polymer increased the extensional viscosity of the blends at high strain rates to levels equal to or greater than silicone oil 5,000. In all cases, the shear viscosity of the blends was lower than that of silicone oil 5,000. The additive blends were qualitatively as emulsification-resistant as silicone oil 5,000.
The addition of low concentrations of very-high-molecular-weight polymers of the same chemistry as the bulk oil has the potential to increase the emulsification resistance of the tamponade agents while maintaining ease of injection and removal.
研究导致临床并发症的硅油栓塞剂的乳化情况。本研究旨在提高硅油 1000 的抗乳化能力，使其至少与硅油 5000 一样抗乳化，同时保持剪切粘度<5000 mPa/s，以利于注射和取出。
在硅油 1000 中分别以 5%和 10%的重量比添加高分子量（423 kDa）聚二甲基硅氧烷。使用毛细管断裂拉伸、旋转剪切和毛细管挤出流变仪分别测量硅油 1000 和 5000 的剪切和拉伸粘度，以及 50:50 的混合物硅油 1000 和 5000，以及 5%和 10%的重量比添加剂混合物。使用 Pluronic F68 或蛋白质溶液作为乳化稳定剂，通过搅拌评估体外乳化情况。
高分子量聚合物的添加将混合物的拉伸粘度提高到与硅油 5000 相等或更高的高应变速率水平。在所有情况下，混合物的剪切粘度均低于硅油 5000。添加剂混合物的抗乳化能力与硅油 5000 一样。
添加与基础油相同化学性质的低浓度超高分子量聚合物有可能提高栓塞剂的抗乳化能力，同时保持注射和取出的容易程度。
