Pilmore Helen, Collins John, Dittmer Ian, Williams Laurie, Carpenter Logan, Thomas Stephen, Croxson Margaret, Thomas Mark
Department of Renal Medicine, Auckland City Hospital, Grafton, Auckland, New Zealand.
Transplantation. 2009 Sep 27;88(6):762-5. doi: 10.1097/TP.0b013e3181b4749f.
Human herpesvirus (HHV)-6 infection is common after organ transplantation; however, most cases are associated with a mild clinical course. Donor-derived infection is rare, and there are no reports of HHV-6 infection in more than one recipient from a common donor.
We describe two patients who developed severe, and in one case fatal, HHV-6 variant A infection after renal transplantation.
Both patients presented with severe colitis followed by the development of liver dysfunction and cytopenia. Multiple specimens from both recipients were positive for HHV-6 polymerase chain reaction variant A. Serum and white cells from the donor were positive for HHV-6 DNA, suggesting a donor-derived infection in these patients.
We report two cases of donor-derived HHV-6 infection from the same deceased donor, resulting in a fatal outcome in one patient. Treatment with valganciclovir was successfully instigated in one patient with a full recovery from the infection.
人类疱疹病毒（HHV）-6感染在器官移植后很常见；然而，大多数病例的临床病程较轻。供体来源的感染很少见，且尚无同一供体感染HHV-6的多个受者的报道。
我们描述了两名肾移植后发生严重的、其中一例致命的HHV-6 A型变异株感染的患者。
两名患者均出现严重结肠炎，随后出现肝功能障碍和血细胞减少。两名受者的多个样本的HHV-6聚合酶链反应A型变异株呈阳性。供体的血清和白细胞的HHV-6 DNA呈阳性，提示这些患者的感染源自供体。
我们报告了两例来自同一已故供体的供体来源的HHV-6感染病例，其中一例患者死亡。一名患者成功接受了缬更昔洛韦治疗，感染完全康复。
