添加维生素A的表面活性剂的表面活性。
Surface activity of surfactant spiked with vitamin A.
作者信息
Bronshtein Vadim, Venkatesh Vugranam, Aulakh Jas, Chessex Philippe
机构信息
Division of Neonatology, Children's and Women's Health Centre of British Columbia, University of British Columbia, 4480 Oak Street, Vancouver, BC, Canada.
出版信息
Drug Des Devel Ther. 2009 Feb 6;2:145-50. doi: 10.2147/dddt.s3255.
BACKGROUND
Intramuscular injections of vitamin A decrease the risk of broncho-pulmonary dysplasia. Admixture of vitamin A with surfactant as a lipophilic vehicle might be a less invasive modality.
AIM
Test physical properties of surfactant + vitamin A.
METHODS
Miscibility and surface activity were tested in surfactant supplemented with retinyl-acetate, -palmitate, 13-cis-, or all-trans-retinoic acid.
RESULTS
Retinol acetate (5000 IU/mL) demonstrated miscibility with surfactant when premixing with ethanol. Its surface activity was 40% lower compared to surfactant alone.
CONCLUSION
These findings warrant preclinical studies to test whether administration of vitamin A in subjects requiring surfactant is associated with beneficial functional properties.
背景
肌肉注射维生素A可降低支气管肺发育不良的风险。将维生素A与作为亲脂性载体的表面活性剂混合可能是一种侵入性较小的方式。
目的
测试表面活性剂+维生素A的物理性质。
方法
在添加了醋酸视黄酯、棕榈酸视黄酯、13-顺式视黄酸或全反式视黄酸的表面活性剂中测试混溶性和表面活性。
结果
醋酸视黄醇（5000 IU/mL）与乙醇预混合时与表面活性剂具有混溶性。其表面活性比单独的表面活性剂低40%。
结论
这些发现值得进行临床前研究，以测试在需要表面活性剂的受试者中给予维生素A是否具有有益的功能特性。
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