Tomioka K, Ishiguro T, Mizuguchi H, Komeshima N, Koga K, Tsukagoshi S, Tsuruo T, Tashiro T, Tanida S, Kishi T
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
J Med Chem. 1991 Jan;34(1):54-7. doi: 10.1021/jm00105a009.
The cytotoxic activities of optically pure and racemic steganacin congeners and analogues against KB cells in culture and the inhibitor activity of cilia regeneration in Tetrahymena were studied with regard to absolute and relative configurations. The stereochemical requirements of dibenzocyclooctadiene lignan lactones for activity were clarified.
研究了光学纯和外消旋隐丹参酮同系物及类似物对培养的KB细胞的细胞毒性活性以及对四膜虫纤毛再生的抑制活性，涉及绝对构型和相对构型。阐明了二苯并环辛二烯木脂素内酯活性的立体化学要求。
