Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA.
J Neurol Sci. 2010 Mar 15;290(1-2):102-6. doi: 10.1016/j.jns.2009.10.020. Epub 2009 Nov 17.
Patient-based rating scales and especially quality of life scales have received increasing attention as secondary outcome measures in multiple sclerosis (MS). Responsiveness to health-related change of quality of life scales is thus an important property when these measures are to be used successfully in clinical trials.
We conducted an analysis of 3 cohorts of MS patients to examine responsiveness of the Hamburg Quality of Life Questionnaire for Multiple Sclerosis (HAQUAMS). One cohort consisted of patients from the outpatient clinic whose overall health status deteriorated over the course of one year (n=53), one study investigated two neurorehabilitation programs (n=20 each) and a third study investigated a low-level aerobic fitness training intervention (n=15).
The total score of the HAQUAMS and several subscales was found to be responsive in all three settings. In addition, we provide minimally important difference (MID) estimates based on anchor- and distribution-based methods for all scales of the HAQUAMS.
The HAQUAMS is responsive to change in observational and intervention studies in MS in adequately powered trials.
基于患者的评分量表，特别是生活质量量表，作为多发性硬化症（MS）的次要结局测量指标，已经受到越来越多的关注。因此，当这些测量指标成功应用于临床试验时，对生活质量量表与健康相关的变化的反应能力是一个重要的特性。
我们对 3 组 MS 患者进行了分析，以检查汉堡多发性硬化症生活质量问卷（HAQUAMS）的反应能力。一个队列由门诊患者组成，他们的整体健康状况在一年中恶化（n=53），一项研究调查了两个神经康复项目（n=20 人），第三个研究调查了低水平的有氧运动训练干预（n=15）。
HAQUAMS 的总分和几个分量表在所有三种情况下都具有反应能力。此外，我们还基于锚定和分布方法为 HAQUAMS 的所有量表提供了最小重要差异（MID）估计。
在多发性硬化症的观察性和干预性研究中，HAQUAMS 在充分有力的试验中对变化具有反应能力。
