Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
Arch Gerontol Geriatr. 2010 Sep-Oct;51(2):164-8. doi: 10.1016/j.archger.2009.10.002. Epub 2009 Nov 17.
Inflammatory cytokines may contribute to lower physical function in elderly. The purpose of this study was to clarify the relation between circulating level of C-reactive protein (CRP) and physical performance among the community-dwelling elderly in Japan. Participants were 803 (329 men and 474 women) aged 65 years and over. Four physical performances were assessed using hand-grip strength, length of time standing on one leg, and walking speed (usual and maximal). Low physical performance was defined as the lowest 25% of study sample in each sex. Multiple logistic regression analysis showed that CRP was negatively associated with physical performance in hand-grip strength (odds ratio=OR=1.86, 95% confidence interval=95% CI=1.32-3.05, OR=2.92, 95% CI=1.53-5.58, for the middle and highest, respectively), time of one leg standing (OR=1.96, 95% CI=1.28-3.00, OR=2.16, 95% CI=1.19-3.92, for the middle and highest, respectively) and maximal walking speed (OR=2.46, 95% CI=1.23-4.93, for the highest) when adjusted for the confounding factors. The results showed the negatively associated between CRP level and physical performance when adjusted for the confounding factors. CRP level may be a useful indicator for detecting the lower physical performance in elderly.
炎症细胞因子可能导致老年人身体机能下降。本研究旨在阐明日本社区居住的老年人循环 C 反应蛋白（CRP）水平与身体机能表现之间的关系。参与者为 803 名（329 名男性和 474 名女性）年龄在 65 岁及以上的老年人。使用握力、单腿站立时间和步行速度（通常和最大速度）评估四项身体机能。低身体机能表现定义为每个性别中研究样本的最低 25%。多因素逻辑回归分析显示，CRP 与握力（比值比[OR]=1.86，95%置信区间[95%CI]=1.32-3.05，OR=2.92，95%CI=1.53-5.58，分别为中值和最高值）、单腿站立时间（OR=1.96，95%CI=1.28-3.00，OR=2.16，95%CI=1.19-3.92，分别为中值和最高值）和最大步行速度（OR=2.46，95%CI=1.23-4.93，最高值）之间呈负相关，在调整混杂因素后。结果表明，在调整混杂因素后，CRP 水平与身体机能表现之间存在负相关。CRP 水平可能是检测老年人较低身体机能表现的有用指标。
