Gordon Y J, Lahav M, Photiou S, Becker Y
Br J Ophthalmol. 1977 Aug;61(8):506-9. doi: 10.1136/bjo.61.8.506.
In the rabbit 5% phosphonoacetic acid ointment suppressed herpetic keratitis as well as 0-5% idoxuridine ointment. After 5 days of treatment quantitative virus titres showed that phosphonoacetic acid was superior to idoxuridine in the inhibition of herpes virus replication. Phosphonoacetic acid was found to be nontoxic to the eye in both clinical and histopathological studies. Recent reports suggest that the mechanism of action of phosphonoacetic acid appears to be the blocking of the virus DNA polymerase, which is essential for the synthesis of herpes virus DNA.
在兔子身上，5%的膦甲酸钠软膏对疱疹性角膜炎的抑制效果与0.5%的碘苷软膏相当。治疗5天后的定量病毒滴度显示，膦甲酸钠在抑制疱疹病毒复制方面优于碘苷。临床和组织病理学研究均表明，膦甲酸钠对眼睛无毒。最近的报告显示，膦甲酸钠的作用机制似乎是阻断病毒DNA聚合酶，而该酶对疱疹病毒DNA的合成至关重要。
