膦甲酸钠治疗实验性单纯疱疹性角膜炎的效果。
Effect of phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.
作者信息
Gordon Y J, Lahav M, Photiou S, Becker Y
出版信息
Br J Ophthalmol. 1977 Aug;61(8):506-9. doi: 10.1136/bjo.61.8.506.
Abstract
In the rabbit 5% phosphonoacetic acid ointment suppressed herpetic keratitis as well as 0-5% idoxuridine ointment. After 5 days of treatment quantitative virus titres showed that phosphonoacetic acid was superior to idoxuridine in the inhibition of herpes virus replication. Phosphonoacetic acid was found to be nontoxic to the eye in both clinical and histopathological studies. Recent reports suggest that the mechanism of action of phosphonoacetic acid appears to be the blocking of the virus DNA polymerase, which is essential for the synthesis of herpes virus DNA.
摘要
在兔子身上，5%的膦甲酸钠软膏对疱疹性角膜炎的抑制效果与0.5%的碘苷软膏相当。治疗5天后的定量病毒滴度显示，膦甲酸钠在抑制疱疹病毒复制方面优于碘苷。临床和组织病理学研究均表明，膦甲酸钠对眼睛无毒。最近的报告显示，膦甲酸钠的作用机制似乎是阻断病毒DNA聚合酶，而该酶对疱疹病毒DNA的合成至关重要。
相似文献
1
Effect of phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.膦甲酸钠治疗实验性单纯疱疹性角膜炎的效果。
Br J Ophthalmol. 1977 Aug;61(8):506-9. doi: 10.1136/bjo.61.8.506.
2
Effect of trisodium phosphonoformate and idoxuridine on experimental herpes simplex keratitis in immunized and non-immunized rabbits.膦甲酸钠三钠和碘苷对免疫和未免疫家兔实验性单纯疱疹性角膜炎的影响。
Acta Ophthalmol (Copenh). 1980 Apr;58(2):167-73. doi: 10.1111/j.1755-3768.1980.tb05705.x.
3
Phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.膦甲酸治疗实验性单纯疱疹性角膜炎
Antimicrob Agents Chemother. 1975 Mar;7(3):285-8. doi: 10.1128/AAC.7.3.285.
4
Phosphonoacetic acid in the treatment of experimental ocular herpes simplex infections.膦甲酸治疗实验性眼部单纯疱疹感染
Antimicrob Agents Chemother. 1976 Feb;9(2):308-11. doi: 10.1128/AAC.9.2.308.
5
Phosphonoacetic acid effective in herpesvirus infection.膦甲酸钠对疱疹病毒感染有效。
Virologie. 1982 Jan-Mar;33(1):73-4.
6
Comparative evaluation of antiherpetic drugs in animal experiments.动物实验中抗疱疹药物的比较评估。
Adv Ophthalmol. 1979;38:43-8.
7
[Chemotherapy of herpetic infections].[疱疹感染的化学疗法]
Vopr Virusol. 1986 Jan-Feb;31(1):6-18.
8
[Acquired idoxuridine resistance of herpes simplex virus. Clinical data (author's transl)].[单纯疱疹病毒获得性碘苷耐药性。临床资料（作者译）]
Sem Hop. 1978;54(33-36):1071-2.
9
Newer compounds in therapy of herpes simplex keratitis.
Arch Ophthalmol. 1967 Nov;78(5):600-5. doi: 10.1001/archopht.1967.00980030602008.
10
[Comparative study of the effectiveness of acycloguanosine and phosphonoacetic acid in herpetic infection in cell cultures].
Vopr Virusol. 1986 Mar-Apr;31(2):210-6.
本文引用的文献
1
Inhibition of herpes simplex virus replication by phosphonoacetic acid.膦甲酸钠对单纯疱疹病毒复制的抑制作用。
Antimicrob Agents Chemother. 1974 Sep;6(3):360-5. doi: 10.1128/AAC.6.3.360.
2
IDU therapy of herpes simplex.单纯疱疹的注射吸毒疗法。 （不过从医学常理看，这个表述不太符合常见医学内容，可能原文有误，正常应该是关于单纯疱疹的某种规范治疗方法表述，比如“Intermittent dosing therapy of herpes simplex”之类，单纯“IDU therapy”这样表述容易误解，这里是按照字面翻译）
Arch Ophthalmol. 1962 May;67:583-91. doi: 10.1001/archopht.1962.00960020583012.
3
Use of 5-iodo-2'-deoxyuridine (IDU) in treatment of herpes simplex keratitis.5-碘-2'-脱氧尿苷（IDU）在单纯疱疹性角膜炎治疗中的应用。
Arch Ophthalmol. 1962 Aug;68:235-9. doi: 10.1001/archopht.1962.00960030239015.
4
The recurrence of herpetic keratitis following idoxuridine therapy.
Am J Ophthalmol. 1967 Jan;63(1):103-7. doi: 10.1016/0002-9394(67)90583-1.
5
The management of ocular herpes.眼部疱疹的管理
Trans Ophthalmol Soc U K (1962). 1967;87:59-84.
6
Suppression of herpes simplex virus infection by phosphonoacetic acid.膦甲酸钠对单纯疱疹病毒感染的抑制作用。
Appl Microbiol. 1973 Sep;26(3):264-7. doi: 10.1128/am.26.3.264-267.1973.
7
The effect of cytosine arabinoside on the replication of herpes simplex virus.
Virology. 1967 Jan;31(1):129-34. doi: 10.1016/0042-6822(67)90016-5.
8
Vidarabine therapy of complicated herpes simplex keratitis.阿糖腺苷治疗复杂性单纯疱疹性角膜炎
Am J Ophthalmol. 1976 May;81(5):642-9. doi: 10.1016/0002-9394(76)90131-8.
9
Phosphonoacetic acid in the treatment of experimental ocular herpes simplex infections.膦甲酸治疗实验性眼部单纯疱疹感染
Antimicrob Agents Chemother. 1976 Feb;9(2):308-11. doi: 10.1128/AAC.9.2.308.
10
Photodynamic inactivation in experimental herpetic keratitis.实验性疱疹性角膜炎中的光动力灭活
Arch Ophthalmol. 1975 Mar;93(3):207-14. doi: 10.1001/archopht.1975.01010020215010.
Zotero 插件