膦甲酸治疗实验性眼部单纯疱疹感染
Phosphonoacetic acid in the treatment of experimental ocular herpes simplex infections.
作者信息
Meyer R F, Varnell E D, Kaufman H E
出版信息
Antimicrob Agents Chemother. 1976 Feb;9(2):308-11. doi: 10.1128/AAC.9.2.308.
Abstract
Phosphonoacetic acid had a significant antiviral effect when applied topically, both in liquid and ointment preparations, on superficial herpetic keratitis in rabbits and was equally as effective as idoxuridine. It was also effective in the treatment of idoxuridine-resistant herpetic keratitis. Phosphonoacetic acid was not effective in the treatment of experimental herpetic iritis when applied topically but was significantly effective when administered intravenously and subconjunctivally. No significant local or systemic toxicity was encountered.
摘要
膦甲酸以液体和软膏制剂局部应用于兔的浅层疱疹性角膜炎时，具有显著的抗病毒作用，且与碘苷同样有效。它对碘苷耐药的疱疹性角膜炎治疗也有效。膦甲酸局部应用于实验性疱疹性虹膜炎治疗无效，但静脉注射和结膜下注射则显著有效。未发现明显的局部或全身毒性。
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本文引用的文献
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Inhibition of DNA polymerase from herpes simplex virus-infected wi-38 cells by phosphonoacetic Acid.膦甲酸对单纯疱疹病毒感染的WI-38细胞中DNA聚合酶的抑制作用。
J Virol. 1975 May;15(5):1281-3. doi: 10.1128/JVI.15.5.1281-1283.1975.
2
Inhibition of herpes simplex virus replication by phosphonoacetic acid.膦甲酸钠对单纯疱疹病毒复制的抑制作用。
Antimicrob Agents Chemother. 1974 Sep;6(3):360-5. doi: 10.1128/AAC.6.3.360.
3
Trifluorothymidine treatment of herpetic iritis in rabbits and ocular penetration.
Invest Ophthalmol. 1973 Jul;12(7):532-4.
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Suppression of herpes simplex virus infection by phosphonoacetic acid.膦甲酸钠对单纯疱疹病毒感染的抑制作用。
Appl Microbiol. 1973 Sep;26(3):264-7. doi: 10.1128/am.26.3.264-267.1973.
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Development of resistance to antiviral drugs.抗病毒药物耐药性的产生。
Ann N Y Acad Sci. 1965 Jul 30;130(1):343-54. doi: 10.1111/j.1749-6632.1965.tb12568.x.
6
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7
Intravenous adenine arabinoside against herpes simplex keratouveitis in humans.静脉注射阿糖腺苷治疗人类单纯疱疹性角膜葡萄膜炎。
Am J Ophthalmol. 1975 Apr;79(4):659-64. doi: 10.1016/0002-9394(75)90807-7.
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Phosphonoacetic acid-resistant herpes simplex virus infection in hairless mice.无毛小鼠中耐膦酰乙酸的单纯疱疹病毒感染
Antimicrob Agents Chemother. 1975 Mar;7(3):289-93. doi: 10.1128/AAC.7.3.289.
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