Meyer R F, Varnell E D, Kaufman H E
Antimicrob Agents Chemother. 1976 Feb;9(2):308-11. doi: 10.1128/AAC.9.2.308.
Phosphonoacetic acid had a significant antiviral effect when applied topically, both in liquid and ointment preparations, on superficial herpetic keratitis in rabbits and was equally as effective as idoxuridine. It was also effective in the treatment of idoxuridine-resistant herpetic keratitis. Phosphonoacetic acid was not effective in the treatment of experimental herpetic iritis when applied topically but was significantly effective when administered intravenously and subconjunctivally. No significant local or systemic toxicity was encountered.
膦甲酸以液体和软膏制剂局部应用于兔的浅层疱疹性角膜炎时，具有显著的抗病毒作用，且与碘苷同样有效。它对碘苷耐药的疱疹性角膜炎治疗也有效。膦甲酸局部应用于实验性疱疹性虹膜炎治疗无效，但静脉注射和结膜下注射则显著有效。未发现明显的局部或全身毒性。
