孕早期和孕中期胎儿眼部缺陷及相关异常的诊断：8例报告。
First- and second-trimester diagnosis of fetal ocular defects and associated anomalies: report of eight cases.
作者信息
Bronshtein M, Zimmer E, Gershoni-Baruch R, Yoffe N, Meyer H, Blumenfeld Z
机构信息
Department of Obstetrics and Gynecology, Rambam Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
出版信息
Obstet Gynecol. 1991 Mar;77(3):443-9.
Ocular cataract, hypertelorism, hypotelorism, anophthalmos, and microphthalmos are rare malformations commonly associated with other fetal anomalies. Previously, ocular malformations were detected only after mid-gestation. Transvaginal sonography allows the detection of many structural fetal anomalies. We describe the case reports of eight ocular anomalies among 1600 fetal screenings by transvaginal sonography at 12-18 weeks' gestation. Severe cataract was correctly diagnosed by transvaginal sonography. However, transvaginal sonography failed to detect moderate cataract in a case of repeat cataract in a subsequent gestation. Anophthalmia may sometimes be secondary to a degenerative process in middle and late pregnancy. In five of the eight described cases, the eye malformations were associated with defects of the central nervous system.
白内障、眼距过宽、眼距过窄、无眼畸形和小眼畸形是罕见的畸形，通常与其他胎儿异常相关。以前，眼部畸形仅在妊娠中期后才能检测到。经阴道超声检查能够检测出许多胎儿结构异常。我们描述了在妊娠12 - 18周时通过经阴道超声对1600例胎儿进行筛查中发现的8例眼部异常病例报告。经阴道超声正确诊断出了严重白内障。然而，在随后妊娠中出现的一例复发性白内障病例中，经阴道超声未能检测出中度白内障。无眼畸形有时可能继发于妊娠中后期的退行性病变。在所描述的8例病例中，有5例眼部畸形与中枢神经系统缺陷相关。
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