自闭症和特定语言障碍中的小脑、语言和认知。
Cerebellum, language, and cognition in autism and specific language impairment.
机构信息
Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02114, USA.
出版信息
J Autism Dev Disord. 2010 Mar;40(3):300-16. doi: 10.1007/s10803-009-0872-7.
Abstract
We performed cerebellum segmentation and parcellation on magnetic resonance images from right-handed boys, aged 6-13 years, including 22 boys with autism [16 with language impairment (ALI)], 9 boys with Specific Language Impairment (SLI), and 11 normal controls. Language-impaired groups had reversed asymmetry relative to unimpaired groups in posterior-lateral cerebellar lobule VIIIA (right side larger in unimpaired groups, left side larger in ALI and SLI), contralateral to previous findings in inferior frontal cortex language areas. Lobule VIIA Crus I was smaller in SLI than in ALI. Vermis volume, particularly anterior I-V, was decreased in language-impaired groups. Language performance test scores correlated with lobule VIIIA asymmetry and with anterior vermis volume. These findings suggest ALI and SLI subjects show abnormalities in neurodevelopment of fronto-corticocerebellar circuits that manage motor control and the processing of language, cognition, working memory, and attention.
摘要
我们对右利手男孩（年龄 6-13 岁）的磁共振图像进行了小脑分割和分区，其中包括 22 名自闭症男孩[16 名有语言障碍（ALI）]、9 名特定语言障碍（SLI）男孩和 11 名正常对照组。语言障碍组在小脑后外侧叶 VIIIA （未受损组右侧较大，ALI 和 SLI 组左侧较大）与先前在额下回语言区发现的结果相反，出现了反转的不对称性。相比于 ALI，SLI 患者的 Crus I 小叶 VIIA 更小。语言障碍组的蚓部体积，特别是前部 I-V 减小。语言表现测试分数与小叶 VIIIA 不对称和前蚓部体积相关。这些发现表明，ALI 和 SLI 患者表现出与管理运动控制以及语言、认知、工作记忆和注意力处理相关的额皮质小脑回路的神经发育异常。
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