Institute of Neuroscience and Pharmacology, Eye Pathology Section, University of Copenhagen, Copenhagen, Denmark.
Acta Ophthalmol. 2011 Nov;89(7):681-5. doi: 10.1111/j.1755-3768.2009.01765.x. Epub 2009 Nov 19.
Cyclooxygenase-2 (COX-2) is an enzyme involved in neoplastic processes. The purpose of the present study is to investigate COX-2 expression in the normal human eye and the expression pattern in selected eye tumours involving COX-2 expressing cells.
Immunohistochemical staining using antibodies against COX-2 was performed on paraffin sections of normal human eyes and selected eye tumours arising from cells expressing COX-2.
Cyclooxygenase-2 expression was found in various structures of the normal eye. Abundant expression was seen in the cornea, iris, ciliary body and retina. The COX-2 expression was less in tumours deriving from the ciliary epithelium and also in retinoblastoma.
Cyclooxygenase-2 is constitutively expressed in normal human eyes. The expression of COX-2 is much lower in selected eye tumours involving COX-2 expressing cells.
环氧化酶-2（COX-2）是参与肿瘤形成过程的一种酶。本研究的目的是调查 COX-2 在正常人类眼中的表达情况，以及在涉及 COX-2 表达细胞的选定眼部肿瘤中的表达模式。
使用针对 COX-2 的抗体对石蜡切片进行免疫组织化学染色，这些切片取自正常人类眼和源自表达 COX-2 的细胞的选定眼部肿瘤。
COX-2 表达在正常眼的各种结构中。在角膜、虹膜、睫状体和视网膜中可见丰富的表达。在源自睫状上皮的肿瘤和视网膜母细胞瘤中，COX-2 的表达较少。
COX-2 在正常人类眼中持续表达。在涉及 COX-2 表达细胞的选定眼部肿瘤中，COX-2 的表达较低。
