National Institute of Science and Technology for Stem Cells and Cell Therapy, Centro Regional de Hemoterapia de Ribeirão Preto - HCFMRP/Universidade de São Paulo, Ribeirão Preto, SP 14051-140, Brazil.
Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):419-27. doi: 10.1016/j.cytogfr.2009.10.002. Epub 2009 Nov 18.
Mesenchymal stem cells (MSCs) have been described as being able to give rise to several quite different mesenchymal cell phenotypes. However, the ability to differentiate is not the only characteristic that makes these cells attractive for therapeutic purposes. The secretion of a broad range of bioactive molecules by MSCs, such as growth factors, cytokines and chemokines, constitutes their most biologically significant role under injury conditions. Understanding this intricate secretory activity as well as the properties of MSCs in vivo is central to harnessing their clinical potential. Herein, we identify some of the molecules involved in the paracrine effects of MSCs with a perspective that these cells intrinsically belong to a perivascular niche in vivo, and discuss how this knowledge could be advantageously used in clinical applications.
间充质干细胞 (MSCs) 被描述为能够产生几种截然不同的间充质细胞表型。然而，分化能力并不是使这些细胞在治疗目的上具有吸引力的唯一特征。MSCs 分泌广泛的生物活性分子，如生长因子、细胞因子和趋化因子，这是它们在损伤条件下最重要的生物学作用。理解这种复杂的分泌活性以及 MSCs 在体内的特性是发挥其临床潜力的关键。在此，我们从细胞本质上属于体内血管周龛位的角度，确定了一些参与 MSC 旁分泌作用的分子，并讨论了如何将这些知识有利地应用于临床应用。
