Center for Molecular Immunology & Infectious Disease and Department of Veterinary & Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Trends Immunol. 2010 Jan;31(1):39-44. doi: 10.1016/j.it.2009.10.001. Epub 2009 Nov 18.
The eosinophil has been perceived as a terminal effector cell in allergic airway diseases. However, recent work has shown that this multifunctional cell could be more involved in the initial stages of allergic disease development than was previously thought, particularly with regard to the ability of the eosinophil to modulate T-cell responses. In this review, we discuss recent advances that suggest that eosinophils can present antigen to naïve as well as to antigen-experienced T cells, induce T helper 2 cell development, cytokine production or both, and affect T-cell migration to sites of inflammation. These findings are changing the way that eosinophil function in disease is perceived, and represent a shift in the dogma of allergic disease development.
嗜酸性粒细胞被认为是过敏性气道疾病的终末效应细胞。然而，最近的研究表明，这种多功能细胞可能比以前认为的更参与过敏性疾病发展的初始阶段，特别是在嗜酸性粒细胞调节 T 细胞反应的能力方面。在这篇综述中，我们讨论了最近的进展，这些进展表明嗜酸性粒细胞可以向幼稚 T 细胞和抗原经历 T 细胞呈递抗原，诱导 T 辅助 2 细胞的发育、细胞因子的产生或两者兼有，并影响 T 细胞向炎症部位的迁移。这些发现正在改变人们对疾病中嗜酸性粒细胞功能的认识，并代表了过敏性疾病发展的教条转变。
