Pesce Silvia, Thoren Fredrik B, Cantoni Claudia, Prato Carola, Moretta Lorenzo, Moretta Alessandro, Marcenaro Emanuela
Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy.
Sahlgrenska Cancer Center, University of Gothenburg, Göteborg, Sweden.
Front Immunol. 2017 Apr 28;8:510. doi: 10.3389/fimmu.2017.00510. eCollection 2017.
Previous studies suggested that the cross talk between NK cells and other cell types is crucial for the regulation of both innate and adaptive immune responses. In the present study, we analyzed the phenotypic and functional outcome of the interaction between resting or cytokine-activated NK cells and eosinophils derived from non-atopic donors. Our results provide the first evidence that a natural cytotoxicity receptor (NCR)/NCR ligand-dependent cross talk between NK cells and eosinophils may be important to upregulate the activation state and the effector function of cytokine-primed NK cells. This interaction also promotes the NK-mediated editing process of dendritic cells that influence the process of Th1 polarization. In turn, this cross talk also resulted in eosinophil activation and acquisition of the characteristic features of antigen-presenting cells. At higher NK/eosinophil ratios, cytokine-primed NK cells were found to kill eosinophils NKp46 and NKp30, thus suggesting a potential immunoregulatory role for NK cells in dampening inflammatory responses involving eosinophils.
先前的研究表明，自然杀伤细胞（NK细胞）与其他细胞类型之间的相互作用对于先天免疫和适应性免疫反应的调节至关重要。在本研究中，我们分析了静息或细胞因子激活的NK细胞与非特应性供体来源的嗜酸性粒细胞之间相互作用的表型和功能结果。我们的结果首次证明，NK细胞与嗜酸性粒细胞之间自然细胞毒性受体（NCR）/NCR配体依赖性的相互作用可能对上调细胞因子预激活的NK细胞的激活状态和效应功能很重要。这种相互作用还促进了NK细胞介导的树突状细胞编辑过程，从而影响Th1极化过程。反过来，这种相互作用也导致嗜酸性粒细胞激活并获得抗原呈递细胞的特征。在较高的NK/嗜酸性粒细胞比例下，发现细胞因子预激活的NK细胞通过NKp46和NKp30杀死嗜酸性粒细胞，因此表明NK细胞在减轻涉及嗜酸性粒细胞的炎症反应中具有潜在的免疫调节作用。
