Finkelstein M M
Health Studies Service, Ontario Ministry of Labour, Toronto, Canada.
Am J Ind Med. 1991;19(2):229-35. doi: 10.1002/ajim.4700190210.
This paper describes an application of the time windows method to an examination of the temporal pattern of lung cancer risk among steel workers. Case-control methodology was utilized. The cases were 36 men who had died of lung cancer and the controls were 289 men who had died of any other cause. The number of years of employment in the steel pouring area was used as a surrogate measure of exposure. The data were examined by contingency table analysis and by logistic regression, which permitted adjustment for exposures in multiple time windows and the use of continuous, rather than categorical, measures of exposure. It was found that lung cancer risk was associated with exposures occurring between 18 and 30 years before death. It cannot yet be determined whether this time course reflects a biological response or the temporal pattern of exposure to an as yet unidentified toxic agent.
本文描述了时间窗方法在钢铁工人肺癌风险时间模式研究中的应用。采用了病例对照研究方法。病例组为36名死于肺癌的男性，对照组为289名死于其他原因的男性。在铸钢区的工作年限被用作暴露的替代指标。通过列联表分析和逻辑回归对数据进行了检验，逻辑回归允许对多个时间窗内的暴露进行调整，并使用连续而非分类的暴露指标。研究发现，肺癌风险与死亡前18至30年之间的暴露有关。目前尚无法确定这种时间进程是反映了生物学反应还是对一种尚未识别的有毒物质的暴露时间模式。
