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低碳钢和不锈钢焊工以及其他金属工人中的癌症发病率。

Cancer incidence among mild steel and stainless steel welders and other metal workers.

作者信息

Hansen K S, Lauritsen J M, Skytthe A

机构信息

Odense Universitet, Faculty of Health Sciences, Institute of Community Health, Denmark.

出版信息

Am J Ind Med. 1996 Oct;30(4):373-82. doi: 10.1002/(SICI)1097-0274(199610)30:4<373::AID-AJIM1>3.0.CO;2-X.

Abstract

The cancer incidence in a historical cohort of 10,059 metal workers employed during the period 1964-1984 was investigated. Standardized incidence ratios (SIR) were calculated based on registry extracts from the Danish Cancer registry. Lifetime exposure data (occupational and other) were obtained by a postal questionnaire in living cohort members and interviews by proxy for deceased and emigrated subjects. The incidence of lung cancer was increased among workers ever "employed as welders" (SIR = 1.38, 95% C.I. 1.03-1.81). There was a significant excess risk of lung cancer among "mild steel (MS) only welders" (SIR = 1.61, 95% C.I. 1.07-2.33) and "nonwelders" (SIR = 1.69, 95% C.I. 1.23-2.26) (indicating carcinogenic exposures other than welding), a borderline significant lung cancer excess among "MS ever welders" (SIR = 1.32, 95% C.I. 0.97-1.76), and a nonsignificant excess risk of lung cancer among "stainless steel (SS) only welders" (SIR = 2.38, 95% C.I. 0.77-5.55). In spite of signs of inconsistency in the risk estimation by duration and latency, we find the results support the conclusions of other studies: employment as a welder is associated with an increased lung cancer risk.

摘要

对1964年至1984年期间受雇的10,059名金属工人的历史队列中的癌症发病率进行了调查。根据丹麦癌症登记处的登记摘录计算标准化发病率(SIR)。通过对在世队列成员进行邮政问卷调查,并通过代理对已故和移民受试者进行访谈,获得终身暴露数据(职业性和其他方面)。曾“从事焊工工作”的工人中肺癌发病率有所增加(SIR = 1.38,95%置信区间1.03 - 1.81)。“仅从事低碳钢(MS)焊接的焊工”(SIR = 1.61,95%置信区间1.07 - 2.33)和“非焊工”(SIR = 1.69,95%置信区间1.23 - 2.26)中肺癌风险显著过高(表明除焊接外的致癌暴露),“曾从事MS焊接的焊工”中肺癌略有显著增加(SIR = 1.32,95%置信区间0.97 - 1.76),“仅从事不锈钢(SS)焊接的焊工”中肺癌风险过高但不显著(SIR = 2.38,95%置信区间0.77 - 5.55)。尽管在按暴露持续时间和潜伏期进行风险估计时存在不一致的迹象,但我们发现结果支持其他研究的结论:从事焊工工作与肺癌风险增加有关。

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