Hansen K S, Lauritsen J M, Skytthe A
Odense Universitet, Faculty of Health Sciences, Institute of Community Health, Denmark.
Am J Ind Med. 1996 Oct;30(4):373-82. doi: 10.1002/(SICI)1097-0274(199610)30:4<373::AID-AJIM1>3.0.CO;2-X.
The cancer incidence in a historical cohort of 10,059 metal workers employed during the period 1964-1984 was investigated. Standardized incidence ratios (SIR) were calculated based on registry extracts from the Danish Cancer registry. Lifetime exposure data (occupational and other) were obtained by a postal questionnaire in living cohort members and interviews by proxy for deceased and emigrated subjects. The incidence of lung cancer was increased among workers ever "employed as welders" (SIR = 1.38, 95% C.I. 1.03-1.81). There was a significant excess risk of lung cancer among "mild steel (MS) only welders" (SIR = 1.61, 95% C.I. 1.07-2.33) and "nonwelders" (SIR = 1.69, 95% C.I. 1.23-2.26) (indicating carcinogenic exposures other than welding), a borderline significant lung cancer excess among "MS ever welders" (SIR = 1.32, 95% C.I. 0.97-1.76), and a nonsignificant excess risk of lung cancer among "stainless steel (SS) only welders" (SIR = 2.38, 95% C.I. 0.77-5.55). In spite of signs of inconsistency in the risk estimation by duration and latency, we find the results support the conclusions of other studies: employment as a welder is associated with an increased lung cancer risk.
对1964年至1984年期间受雇的10,059名金属工人的历史队列中的癌症发病率进行了调查。根据丹麦癌症登记处的登记摘录计算标准化发病率（SIR）。通过对在世队列成员进行邮政问卷调查，并通过代理对已故和移民受试者进行访谈，获得终身暴露数据（职业性和其他方面）。曾“从事焊工工作”的工人中肺癌发病率有所增加（SIR = 1.38，95%置信区间1.03 - 1.81）。“仅从事低碳钢（MS）焊接的焊工”（SIR = 1.61，95%置信区间1.07 - 2.33）和“非焊工”（SIR = 1.69，95%置信区间1.23 - 2.26）中肺癌风险显著过高（表明除焊接外的致癌暴露），“曾从事MS焊接的焊工”中肺癌略有显著增加（SIR = 1.32，95%置信区间0.97 - 1.76），“仅从事不锈钢（SS）焊接的焊工”中肺癌风险过高但不显著（SIR = 2.38，95%置信区间0.77 - 5.55）。尽管在按暴露持续时间和潜伏期进行风险估计时存在不一致的迹象，但我们发现结果支持其他研究的结论：从事焊工工作与肺癌风险增加有关。
