Queen Mary University of London, Centre for Neuroscience and Trauma, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, London E1 2AT, UK.
J Pathol. 2010 Jan;220(2):114-25. doi: 10.1002/path.2651.
The functional significance of changes in nuclear structure and organization in transformed cells remains one of the most enigmatic questions in cancer biology. In this review, we discuss relationships between nuclear organization and transcription in terms of the three-dimensional arrangement of genes in the interphase cancer nucleus and the regulatory functions of nuclear matrix proteins. We also analyse the role of nuclear topology in the generation of gene fusions. We speculate that this type of multi-layered analysis will one day provide a framework for a more comprehensive understanding of the genetic origins of cancer and the identification of new therapeutic targets.
核结构和组织变化在转化细胞中的功能意义仍然是癌症生物学中最神秘的问题之一。在这篇综述中，我们根据间期癌细胞核中基因的三维排列和核基质蛋白的调节功能，讨论了核组织与转录之间的关系。我们还分析了核拓扑在基因融合产生中的作用。我们推测，这种多层次的分析有朝一日将为更全面地了解癌症的遗传起源和确定新的治疗靶点提供一个框架。
