Ando Yoshihito, Sawada Mikio, Morita Mitsuya, Kawamura Mitsuru, Nakano Imaharu
Division of Neurology, Department of Medicine, Jichi Medical University.
Rinsho Shinkeigaku. 2009 Sep;49(9):560-5. doi: 10.5692/clinicalneurol.49.560.
A 65-year-old right-handed man noted a sudden onset of numbness and weakness of the right hand. On the initial visit to our hospital, he showed severe acalculia, and transient agraphia (so called incomplete Gerstmann syndrome) and transcortical sensory aphasia. Brain MRI revealed a fresh infarct in the left middle frontal gyrus. The paragraphia and aphasia improved within 14 days after onset, but the acalculia persisted even at seven months after onset In an 123I-IMP SPECT study, the cerebral blood flow (CBF) was found to be decreased in the infarction lesion and its adjacent wide area, the ipsilateral angular and supramarginal gyri, and contralateral cerebellar hemisphere. We speculate that inactivation in the infarction lesion caused the CBF decrease in the non-infarcted areas due to diaschisis. This case indicates that Gerstmann syndrome can be caused by not only dysfunction of the angular gyrus but also of the left middle frontal gyrus in the dominant hemisphere.
一名65岁右利手男性,突然出现右手麻木和无力。初次来我院就诊时,他表现出严重的失算症、短暂性失写症(所谓的不完全格斯特曼综合征)和经皮质感觉性失语。脑部MRI显示左侧额中回有新鲜梗死灶。书写障碍和失语在发病后14天内有所改善,但失算症在发病7个月后仍持续存在。在一项123I-IMP SPECT研究中,发现梗死灶及其相邻的广泛区域、同侧角回和缘上回以及对侧小脑半球的脑血流量(CBF)减少。我们推测,梗死灶内的失活由于远隔效应导致非梗死区域的CBF降低。该病例表明,格斯特曼综合征不仅可由角回功能障碍引起,也可由优势半球的左侧额中回功能障碍引起。