Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.
ACS Nano. 2009 Dec 22;3(12):3854-60. doi: 10.1021/nn9010126.
Herein, we report on near-infrared (NIR) fluorescent nanoparticles generated from an emergent class of materials we refer to as a Group of Uniform Materials Based on Organic Salts (GUMBOS). GUMBOS are largely frozen ionic liquids, although the concept is more general and is also easily applied to solid ionic materials with melting points in excess of 100 degrees C. Nanoparticles based on GUMBOS (nanoGUMBOS) derived from a NIR fluorophore are prepared using a reprecipitation method and evaluated for in vivo fluorescence imaging. Due to their uniformity, single-step preparation, and composite nature, nanoGUMBOS help to resolve issues with dye leakage problems innate to alternate cellular stains and unlock a myriad of applications for these materials, highlighting exciting possibilities for multifunctional nanoGUMBOS.
在这里，我们报告了近红外（NIR）荧光纳米粒子的产生，这些纳米粒子来自一类新兴的材料，我们称之为基于有机盐的均匀材料组（GUMBOS）。GUMBOS 主要是冻结的离子液体，尽管这个概念更普遍，也很容易应用于熔点超过 100°C 的固态离子材料。基于 GUMBOS（nanoGUMBOS）的纳米粒子是通过再沉淀法制备的，并对其进行体内荧光成像评估。由于其均匀性、一步制备和复合材料的性质，nanoGUMBOS 有助于解决替代细胞染色剂固有的染料泄漏问题，并为这些材料解锁了无数的应用，为多功能 nanoGUMBOS 带来了令人兴奋的可能性。
