Dewhirst Mark W
Radiation Oncology Department, Duke University Medical Center, Durham, Durham, NC 27710, USA.
Radiat Res. 2009 Dec;172(6):653-65. doi: 10.1667/RR1926.1.
This Failla Lecture focused on the inter-relationships between tumor angiogenesis, HIF-1 expression and radiotherapy responses. A common thread that bonds all of these factors together is microenvironmental stress caused by reactive oxygen and nitrogen species formed during tumor growth and angiogenesis or in response to cytotoxic treatment. In this review we focus on one aspect of the crossroad between oxidative stress and angiogenesis, namely cycling hypoxia. Understanding of the relative importance of this feature of the tumor microenvironment has recently expanded; it influences tumor biology in ways that are separate from chronic hypoxia. Cycling hypoxia can influence angiogenesis, treatment responses and metastatic behavior. It represents an important and relatively less well understood feature of tumor biology that requires additional research.
本次法伊拉讲座聚焦于肿瘤血管生成、缺氧诱导因子-1（HIF-1）表达与放疗反应之间的相互关系。将所有这些因素联系在一起的一个共同主线是肿瘤生长和血管生成过程中或对细胞毒性治疗产生反应时形成的活性氧和氮物种所导致的微环境应激。在本综述中，我们关注氧化应激与血管生成交叉点的一个方面，即循环性缺氧。最近，对肿瘤微环境这一特征的相对重要性的认识有所扩展；它以与慢性缺氧不同的方式影响肿瘤生物学。循环性缺氧可影响血管生成、治疗反应和转移行为。它代表了肿瘤生物学中一个重要但相对了解较少的特征，需要进一步研究。
