用于无创血流动力学成像的联合高光谱和光谱域光学相干断层扫描显微镜
Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging.
作者信息
Skala Melissa C, Fontanella Andrew, Hendargo Hansford, Dewhirst Mark W, Izatt Joseph A
机构信息
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
出版信息
Opt Lett. 2009 Feb 1;34(3):289-91. doi: 10.1364/ol.34.000289.
Abstract
We have combined hyperspectral imaging with spectral domain optical coherence tomography (SDOCT) to noninvasively image changes in hemoglobin saturation, blood flow, microvessel morphology, and sheer rate on the vessel wall with tumor growth. Changes in these hemodynamic variables were measured over 24 h in dorsal skin fold window chamber tumors. There was a strong correlation between volumetric flow and hemoglobin saturation (rho=0.89, p=9x10(-6), N=15) and a moderate correlation between shear rate on the vessel wall and hemoglobin saturation (rho=0.56, p=0.03, N=15).
摘要
我们将高光谱成像与光谱域光学相干断层扫描（SDOCT）相结合，以无创方式成像随着肿瘤生长，血红蛋白饱和度、血流、微血管形态以及血管壁上的切变率的变化。在背部皮肤褶皱窗口室肿瘤中，对这些血液动力学变量的变化进行了24小时的测量。体积流量与血红蛋白饱和度之间存在强相关性（rho = 0.89，p = 9×10⁻⁶，N = 15），血管壁上的切变率与血红蛋白饱和度之间存在中度相关性（rho = 0.56，p = 0.03，N = 15）。
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本文引用的文献
1
Speckle variance detection of microvasculature using swept-source optical coherence tomography.
Opt Lett. 2008 Jul 1;33(13):1530-2. doi: 10.1364/ol.33.001530.
2
High-flow-velocity and shear-rate imaging by use of color Doppler optical coherence tomography.
Opt Lett. 1999 Nov 15;24(22):1584-6. doi: 10.1364/ol.24.001584.
3
Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor.
Cancer Res. 2006 Feb 15;66(4):2219-23. doi: 10.1158/0008-5472.CAN-03-2958.
4
Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development.
J Biomed Opt. 2005 Jul-Aug;10(4):44004. doi: 10.1117/1.2003369.
5
Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience.
Gastrointest Endosc. 2005 Jun;61(7):879-90. doi: 10.1016/s0016-5107(05)00323-8.
6
7
Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats.
Am J Physiol. 1999 Aug;277(2):H551-68. doi: 10.1152/ajpheart.1999.277.2.H551.
8
Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation.
Nat Med. 1997 Feb;3(2):177-82. doi: 10.1038/nm0297-177.
9
Microvascular studies on the origins of perfusion-limited hypoxia.
Br J Cancer Suppl. 1996 Jul;27:S247-51.
10
Arteriolar oxygenation in tumour and subcutaneous arterioles: effects of inspired air oxygen content.
Br J Cancer Suppl. 1996 Jul;27:S241-6.
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