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色氨酸衍生物的合成、转化和药物应用。

Syntheses, transformations and pharmaceutical applications of kynurenic acid derivatives.

机构信息

Institute of Pharmaceutical Chemistry and Research Group for Stereochemistry, Hungarian Academy of Sciences, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary.

出版信息

Curr Med Chem. 2009;16(36):4828-42. doi: 10.2174/092986709789909602.

DOI:10.2174/092986709789909602
PMID:19929784
Abstract

The syntheses and transformations of 4-hydroxyquinoline-2-carboxylic acid, kynurenic acid, are reviewed, and special attention is paid to the pharmacological activities and pharmaceutical applications of its derivatives.

摘要

综述了 4-羟基喹啉-2-羧酸、犬尿喹啉酸的合成与转化,并特别关注了其衍生物的药理学活性和药物应用。

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1
Syntheses, transformations and pharmaceutical applications of kynurenic acid derivatives.色氨酸衍生物的合成、转化和药物应用。
Curr Med Chem. 2009;16(36):4828-42. doi: 10.2174/092986709789909602.
2
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Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists.犬尿喹啉酸酰胺作为新型NR2B选择性N-甲基-D-天冬氨酸受体拮抗剂
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Synthesis of New C-3 Substituted Kynurenic Acid Derivatives.新型 C-3 取代色氨酸酸衍生物的合成。
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KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect.含修饰骨架的 KYNA 衍生物;具有潜在神经保护作用的羟基喹啉。
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Structure-function relationships for kynurenic acid analogues at excitatory pathways in the rat hippocampal slice.犬尿喹啉酸类似物在大鼠海马切片兴奋性通路中的结构-功能关系
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Protective compounds in animal models of trigeminal activation and neurodegeneration.三叉神经激活和神经退行性变动物模型中的保护性化合物。
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Multifunctional Analogs of Kynurenic Acid for the Treatment of Alzheimer's Disease: Synthesis, Pharmacology, and Molecular Modeling Studies.用于治疗阿尔茨海默病的犬尿氨酸多功能类似物:合成、药理学及分子模拟研究
ACS Chem Neurosci. 2017 Dec 20;8(12):2667-2675. doi: 10.1021/acschemneuro.7b00229. Epub 2017 Sep 8.

引用本文的文献

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-quinone methide driven synthesis of kynurenic acid lactams.-醌甲基化物驱动的犬尿氨酸内酰胺的合成。
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2
C-3 alkoxymethylation of 4-oxo-1,4-dihydroquinoline 2-carboxylic acid esters organic additives.4-氧代-1,4-二氢喹啉-2-羧酸酯的C-3烷氧基甲基化 有机添加剂
Heliyon. 2024 May 31;10(11):e32188. doi: 10.1016/j.heliyon.2024.e32188. eCollection 2024 Jun 15.
3
Differential Effects of Hypothermia and SZR72 on Cerebral Kynurenine and Kynurenic Acid in a Piglet Model of Hypoxic-Ischemic Encephalopathy.
低温和 SZR72 对缺氧缺血性脑病幼猪模型中脑内犬尿氨酸和犬尿喹啉酸的差异影响。
Int J Mol Sci. 2023 Sep 25;24(19):14522. doi: 10.3390/ijms241914522.
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Synthesis of Indole-Coupled KYNA Derivatives via C-N Bond Cleavage of Mannich Bases.通过曼尼希碱的 C-N 键断裂合成吲哚偶联的 KYNA 衍生物。
Int J Mol Sci. 2022 Jun 28;23(13):7152. doi: 10.3390/ijms23137152.
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Synthetic- and DFT modelling studies on regioselective modified Mannich reactions of hydroxy-KYNA derivatives.羟基犬尿喹啉酸衍生物区域选择性修饰曼尼希反应的合成及密度泛函理论建模研究
RSC Adv. 2020 Dec 24;11(1):543-554. doi: 10.1039/d0ra08325a. eCollection 2020 Dec 21.
6
Kynurenic Acid and Its Analog SZR104 Exhibit Strong Antiinflammatory Effects and Alter the Intracellular Distribution and Methylation Patterns of H3 Histones in Immunochallenged Microglia-Enriched Cultures of Newborn Rat Brains.犬尿酸及其类似物 SZR104 具有很强的抗炎作用,并改变免疫应激新生大鼠脑小胶质细胞富集培养物中 H3 组蛋白的细胞内分布和甲基化模式。
Int J Mol Sci. 2022 Jan 19;23(3):1079. doi: 10.3390/ijms23031079.
7
KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect.含修饰骨架的 KYNA 衍生物;具有潜在神经保护作用的羟基喹啉。
Int J Mol Sci. 2021 Nov 3;22(21):11935. doi: 10.3390/ijms222111935.
8
Kynurenic Acid and Its Synthetic Derivatives Protect Against Sepsis-Associated Neutrophil Activation and Brain Mitochondrial Dysfunction in Rats.犬尿氨酸及其合成衍生物可防止大鼠脓毒症相关中性粒细胞激活和脑线粒体功能障碍。
Front Immunol. 2021 Aug 12;12:717157. doi: 10.3389/fimmu.2021.717157. eCollection 2021.
9
Role of Kynurenine Pathway in Oxidative Stress during Neurodegenerative Disorders.犬尿氨酸途径在神经退行性疾病氧化应激中的作用。
Cells. 2021 Jun 26;10(7):1603. doi: 10.3390/cells10071603.
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The Kynurenic Acid Analog SZR72 Enhances Neuronal Activity after Asphyxia but Is Not Neuroprotective in a Translational Model of Neonatal Hypoxic Ischemic Encephalopathy.犬尿酸类似物 SZR72 可增强窒息后神经元的活性,但在新生儿缺氧缺血性脑病的转化模型中没有神经保护作用。
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