Karolinska Institute, Stockholm, Sweden.
BMC Infect Dis. 2009 Nov 20;9:181. doi: 10.1186/1471-2334-9-181.
Immunization coverage in many parts of Nigeria is far from optimal, and far from equitable.Nigeria accounts for half of the deaths from Measles in Africa, the highest prevalence of circulating wild poliovirus in the world, and the country is among the ten countries in the world with vaccine coverage below 50 percent. Studies focusing on community-level determinants therefore have serious policy implications
Multilevel multivariable regression analysis was used on a nationally-representative sample of women aged 15-49 years from the 2003 Nigeria Demographic and Health Survey. Multilevel regression analysis was performed with children (level 1) nested within mothers (level 2), who were in turn nested within communities (level 3).
Results show that the pattern of full immunization clusters within families and communities, and that socio-economic characteristics are important in explaining the differentials in full immunization among the children in the study. At the individual level, ethnicity, mothers' occupation, and mothers' household wealth were characteristics of the mothers associated with full immunization of the children. At the community level, the proportion of mothers that had hospital delivery was a determinant of full immunization status.
Significant community-level variation remaining after having controlled for child- and mother-level characteristics is indicative of a need for further research on community-levels factors, which would enable extensive tailoring of community-level interventions aimed at improving full immunization and other child health outcomes.
尼日利亚许多地区的免疫接种率远非最佳,也远非公平。尼日利亚占非洲麻疹死亡人数的一半,是世界上循环野生脊髓灰质炎病毒流行率最高的国家,也是全球疫苗接种率低于 50%的十个国家之一。因此,关注社区层面决定因素的研究具有重要的政策意义。
利用 2003 年尼日利亚人口与健康调查中年龄在 15-49 岁的代表性妇女全国样本进行多层次多变量回归分析。采用多层次回归分析,将儿童(第 1 层)嵌套在母亲(第 2 层)中,而母亲又嵌套在社区(第 3 层)中。
结果表明,完全免疫接种的模式在家庭和社区中呈聚集性,社会经济特征在解释研究中儿童完全免疫接种差异方面很重要。在个体层面上,族裔、母亲的职业和母亲家庭的财富是与儿童完全免疫接种相关的母亲特征。在社区层面上,有医院分娩经历的母亲比例是完全免疫接种状况的决定因素。
在控制了儿童和母亲层面的特征后,仍存在显著的社区层面差异,这表明需要进一步研究社区层面的因素,这将使广泛调整旨在改善完全免疫接种和其他儿童健康结果的社区层面干预措施成为可能。