Department of Health, Behavior & Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA,
BMC Infect Dis. 2009 Nov 25;9:185. doi: 10.1186/1471-2334-9-185.
Liver cancer is one of most commonly diagnosed cancers among Koreans. Chronic hepatitis B virus (HBV) infection is a major risk factor for liver cancer. HBV infection can be prevented by effective screening and vaccination programs. The purpose of this study is to examine the status of HBV infection and the predictors associated with HBV vaccination.
The study population was derived from the 2005 Korea National Cancer Screening Survey (KNCSS). The KNCSS is an annual cross-sectional survey that uses a nationally-representative random sampling to investigate cancer screening rates. A total of 1,786 Koreans over 40 years of age participated in this study.
Of all the participants, 5.9% reported HBV positive (HBsAg+, HBsAb-), 41.8% were HBV negative but protected (HBsAg-, HBsAb+), and 52.3% were unprotected (HBsAg-, HBsAb-). Among unprotected individuals (n = 934), 23.1% reported to have received the vaccination. About half of those who had vaccinations completed the 3-shot vaccine series. In multiple analyses, education, having private cancer insurance, alcohol use, having regular check-up, and doing regular exercise were associated with completed HBV vaccination.
This study result suggests that we need a liver cancer education program to increase HBV awareness and to increase the liver cancer prevention message among low educated populations.
肝癌是韩国最常见的癌症之一。慢性乙型肝炎病毒（HBV）感染是肝癌的主要危险因素。通过有效的筛查和疫苗接种计划可以预防 HBV 感染。本研究的目的是调查 HBV 感染状况以及与 HBV 疫苗接种相关的预测因素。
研究人群来自于 2005 年韩国国家癌症筛查调查（KNCSS）。KNCSS 是一项年度横断面调查，采用全国代表性的随机抽样方法调查癌症筛查率。共有 1786 名 40 岁以上的韩国人参与了这项研究。
在所有参与者中，5.9%报告 HBV 阳性（HBsAg+，HBsAb-），41.8%为 HBV 阴性但有保护力（HBsAg-，HBsAb+），52.3%为无保护力（HBsAg-，HBsAb-）。在无保护力者（n=934）中，23.1%报告已接种疫苗。约一半接种过疫苗的人完成了 3 针疫苗系列。在多项分析中，教育程度、拥有私人癌症保险、饮酒、定期检查和定期锻炼与完成 HBV 疫苗接种有关。
本研究结果表明，我们需要开展肝癌教育计划，以提高 HBV 意识，并向教育程度较低的人群传递肝癌预防信息。
