迈向个性化医疗道路上卫生系统变革的关键方面。

Key aspects of health system change on the path to personalized medicine.

作者信息

Downing Gregory J

机构信息

Personalized Health Care Initiative, Office of the Secretary, Department of Health and Human Services, Hubert H. Humphrey Building, Suite 445F.5, 200 Independence Avenue SW, Washington, DC 20201, USA.

出版信息

Transl Res. 2009 Dec;154(6):272-6. doi: 10.1016/j.trsl.2009.09.003. Epub 2009 Oct 6.

DOI:10.1016/j.trsl.2009.09.003

PMID:19931192

Abstract

The tools and knowledge base for personalized medicine practices are being developed as a major transformation is underway in our health care system. Although the foundation supporting the scientific and technological applications that enable individualized approaches in health care continues to be framed, an uncertain health care delivery landscape lies ahead, driven by economic, quality-of-care, and other policy considerations. There are commonalities in the needs and the opportunities for personalized medicine and health care system change, and these 2 facets can mutually inform one another. Here, we examine this interface in the dimensions of innovation and costs, health information technology, evidence development and comparative effectiveness, clinical data standards, consumer tools, and patient safety and public health. Indeed, personalized medicine must offer solutions for broader health priorities if it is to achieve its potential impact.

摘要

随着我们的医疗保健系统正在经历重大变革，个性化医疗实践的工具和知识库正在不断发展。尽管支持实现医疗保健个性化方法的科学技术应用的基础仍在构建之中，但受经济、医疗质量及其他政策因素驱动，未来的医疗保健服务格局仍不明朗。个性化医疗与医疗保健系统变革在需求和机遇方面存在共性，这两个方面可以相互借鉴。在此，我们从创新与成本、健康信息技术、证据开发与比较效果、临床数据标准、消费者工具以及患者安全与公共卫生等维度审视这一交叉领域。事实上，个性化医疗若要实现其潜在影响，就必须为更广泛的健康优先事项提供解决方案。