School of Nursing, Virginia Commonwealth University, 1100 East Leigh Street, Richmond, VA 23298, USA.
Biol Res Nurs. 2010 Apr;11(4):387-94. doi: 10.1177/1099800409348328. Epub 2009 Nov 22.
Fibromyalgia (FMS) is a chronic widespread pain (CWP) and fatigue syndrome that affects three to six million adults in the United States. Core symptoms of FMS include pain, fatigue, and mood and sleep disturbances. To date, consensus has not been reached among researchers regarding the pathogenesis of FMS nor the specific role of cytokine activation on the neuroendocrine-immune response patterns in persons with FMS. The purpose of this article is to describe and synthesize the results of research studies focused on the relationship between cytokines and FMS and among cytokines and core symptoms of FMS. There is some support in the literature for relationships among FMS symptoms and cytokines; however, there are discrepant findings related to whether proinflammatory and anti-inflammatory cytokines are elevated or reduced in persons with FMS and whether their levels correlate with the core symptoms of this disorder. Although the use of cytokine biomarkers must be considered exploratory at this time due to the lack of consistent empirical findings, biobehavioral research focused on understanding the relationship of FMS with cytokines may lead to a better understanding of this complex syndrome. This knowledge may ultimately contribute to the development of interventions for symptom management that address not only the symptom manifestation but also a biological mediator of symptoms.
纤维肌痛症（FMS）是一种慢性广泛性疼痛（CWP）和疲劳综合征，影响美国三到六百万成年人。FMS 的核心症状包括疼痛、疲劳、情绪和睡眠障碍。迄今为止，研究人员尚未就 FMS 的发病机制以及细胞因子激活对 FMS 患者神经内分泌免疫反应模式的具体作用达成共识。本文旨在描述和综合有关细胞因子与 FMS 之间以及细胞因子与 FMS 核心症状之间关系的研究结果。有一些文献支持 FMS 症状与细胞因子之间的关系；然而，关于 FMS 患者中促炎细胞因子和抗炎细胞因子是否升高或降低，以及它们的水平是否与该疾病的核心症状相关，存在不一致的发现。尽管由于缺乏一致的经验发现，目前使用细胞因子生物标志物必须被视为探索性的，但专注于理解 FMS 与细胞因子关系的生物行为研究可能会更好地理解这种复杂的综合征。这些知识最终可能有助于开发针对症状管理的干预措施，不仅解决症状表现，还解决症状的生物学介质。
