BIRC, NIG Waterfront Bio-IT Research Building, 4-7 Aomi, Tokyo 135-0064, Japan.
Nucleic Acids Res. 2010 Jan;38(Database issue):D626-32. doi: 10.1093/nar/gkp1020. Epub 2009 Nov 23.
We report the extended database and data mining resources newly released in the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/). H-InvDB is a comprehensive annotation resource of human genes and transcripts, and consists of two main views and six sub-databases. The latest release of H-InvDB (release 6.2) provides the annotation for 219,765 human transcripts in 43,159 human gene clusters based on human full-length cDNAs and mRNAs. H-InvDB now provides several new annotation features, such as mapping of microarray probes, new gene models, relation to known ncRNAs and information from the Glycogene database. H-InvDB also provides useful data mining resources-'Navigation search', 'H-InvDB Enrichment Analysis Tool (HEAT)' and web service APIs. 'Navigation search' is an extended search system that enables complicated searches by combining 16 different search options. HEAT is a data mining tool for automatically identifying features specific to a given human gene set. HEAT searches for H-InvDB annotations that are significantly enriched in a user-defined gene set, as compared with the entire H-InvDB representative transcripts. H-InvDB now has web service APIs of SOAP and REST to allow the use of H-InvDB data in programs, providing the users extended data accessibility.
我们报告了在 H-Invitational 数据库（H-InvDB；http://www.h-invitational.jp/）中最新发布的扩展数据库和数据挖掘资源。H-InvDB 是一个全面注释人类基因和转录本的资源，由两个主要视图和六个子数据库组成。H-InvDB 的最新版本（版本 6.2）基于人类全长 cDNA 和 mRNA，为 43159 个人类基因簇中的 219765 个人类转录本提供了注释。H-InvDB 现在提供了一些新的注释特征，例如微阵列探针的映射、新的基因模型、与已知 ncRNAs 的关系以及 Glycogene 数据库的信息。H-InvDB 还提供了有用的数据挖掘资源——“导航搜索”、“H-InvDB 富集分析工具（HEAT）”和 Web 服务 API。“导航搜索”是一个扩展的搜索系统，通过组合 16 种不同的搜索选项，可以进行复杂的搜索。HEAT 是一种数据挖掘工具，用于自动识别给定人类基因集特有的特征。HEAT 搜索 H-InvDB 注释，与整个 H-InvDB 代表性转录本相比，这些注释在用户定义的基因集中显著富集。H-InvDB 现在具有 SOAP 和 REST 的 Web 服务 API，允许在程序中使用 H-InvDB 数据，为用户提供了扩展的数据可访问性。
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