Brown University, Center for Alcohol and Addiction Studies, Providence, RI 02912, USA.
Nicotine Tob Res. 2010 Jan;12(1):19-28. doi: 10.1093/ntr/ntp167. Epub 2009 Nov 23.
The study objectives were to examine smoking abstinence and reinstatement effects on subjective experience and cognitive performance among adolescent smokers.
Adolescents (aged 14-17 years, 60 daily smokers and 32 nonsmokers) participated. Participants completed baseline assessments (Session 1) and returned to the laboratory 1-3 days later to repeat assessments (Session 2); half of the smokers were randomly assigned to 15-17 hr tobacco abstinence preceding Session 2.
During Session 2, abstaining smokers reported significantly greater increases in withdrawal symptoms, smoking urges, and negative affect compared with smokers who did not abstain and compared with nonsmokers. Smoking reinstatement reversed abstinence effects, returning to baseline levels for smoking urges and negative affect. Abstaining smokers showed significantly enhanced cognitive performance on two of six tasks (two-letter search compared with nonabstaining smokers; serial reaction time compared with nonsmokers); smoking reinstatement resulted in significant decrements on these two tasks relative to nonabstaining smokers.
Effects of smoking abstinence and reinstatement on self-report measures are consistent with earlier research with adolescent as well as adult smokers and may help to elucidate the motivational underpinnings of smoking maintenance among adolescent smokers. Effects found on cognitive performance were contrary to hypotheses; further research is needed to understand better the role of cognitive performance effects in smoking maintenance among adolescents.
本研究旨在探讨青少年吸烟者戒烟和复吸对主观体验和认知表现的影响。
共纳入 60 名每日吸烟的青少年吸烟者和 32 名非吸烟者。参与者完成基线评估(第 1 次就诊),并在 1-3 天后返回实验室重复评估(第 2 次就诊);一半的吸烟者在第 2 次就诊前被随机分配进行 15-17 小时的烟草禁欲。
在第 2 次就诊时,与未戒烟者和非吸烟者相比,戒烟者的戒断症状、吸烟欲望和负性情绪显著增加。复吸逆转了戒断效应,使吸烟欲望和负性情绪恢复到基线水平。与非戒烟者相比,戒烟者在六项任务中的两项(两字母搜索任务与非戒烟者相比;序列反应时间与非吸烟者相比)上表现出显著增强的认知表现;与非戒烟者相比,复吸者在这两项任务上的表现明显下降。
吸烟戒断和复吸对自我报告测量的影响与早期对青少年和成年吸烟者的研究一致,可能有助于阐明青少年吸烟者吸烟维持的动机基础。在认知表现方面的发现与假设相反;需要进一步的研究来更好地理解认知表现对青少年吸烟维持的作用。