College of Nursing, University of Florida, Health Science Center, Gainesville, FL 32610, USA.
Biol Res Nurs. 2010 Jan;11(3):261-8. doi: 10.1177/1099800409341175. Epub 2009 Nov 23.
The purpose of this study was to longitudinally describe changes in heart rate variability (HRV) from 28 to 34 weeks postmenstrual age (PMA). A convenience sample of 31 low-risk preterm infants participated. HRV was quantified using a spectral analysis of heart periods and recorded during seven weekly test sessions from an electrocardiogram (ECG) signal. The total range of frequency components (0.04-2.0 Hz), high-frequency (HF) components (0.30-1.3 Hz), and ratio of low-to-high frequency (LF/HF) components (0.04-0.20/ 0.30-1.3 Hz) were measured. A mixed general linear model analysis revealed no significant change over weekly test sessions for the total, the high, and the ratio of LF/HF components. A significant interaction effect was, however, noted in the HF components for test session x gender (df = 1; F = 4.85; p = .030). With increasing age, the HF components for females increased or displayed a pattern of HRV indicative of a more mature autonomic nervous system (ANS). Study findings warrant further investigation of the impact of gender on normative descriptions of HRV.
本研究旨在从末次月经后 28 周到 34 周（PMA）的时间范围内，纵向描述心率变异性（HRV）的变化。本研究纳入了 31 名低危早产儿。采用心电信号（ECG）的频谱分析来量化 HRV，并在每周的 7 次测试中记录 HRV。总频率成分范围（0.04-2.0 Hz）、高频（HF）成分（0.30-1.3 Hz）和低频与高频之比（LF/HF）成分（0.04-0.20/0.30-1.3 Hz）。混合广义线性模型分析显示，总、高和 LF/HF 比值的 HRV 成分在每周的测试中没有显著变化。然而，HF 成分的测试会话与性别之间存在显著的交互效应（df = 1；F = 4.85；p =.030）。随着年龄的增长，女性的 HF 成分增加，或呈现出一种提示自主神经系统（ANS）更成熟的 HRV 模式。研究结果表明，有必要进一步研究性别对 HRV 正常描述的影响。
