Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, 106 Research Drive, Durham, NC 27710, USA.
Proc Am Thorac Soc. 2009 Dec 1;6(7):602-6. doi: 10.1513/pats.200907-078RM.
A comprehensive appreciation of mechanisms regulating epithelial maintenance and repair in pulmonary airways is fundamental to our understanding of tissue remodeling and dysfunction in chronic lung disease. This review provides an update on current concepts that have emerged from recent work in the field of airway epithelial repair and progenitor cell biology. New models to investigate the behavior of lung epithelial progenitor cells have provided fresh insights into their regulation and organization, and help to clarify their roles in normal maintenance and repair. Emerging technologies for the fractionation and culture of lung epithelial cells also provide opportunities to investigate the behavior and regulation of progenitor cell subsets in controlled systems. These advances hold promise for development of new strategies to modulate epithelial cell behavior and to effect tissue repair in the setting of lung disease.
全面认识调控肺气道上皮细胞维持和修复的机制，是理解慢性肺部疾病中组织重塑和功能障碍的基础。本文综述了气道上皮修复和祖细胞生物学领域的最新研究进展，阐述了目前的一些新观点。新的肺上皮祖细胞行为研究模型为其调控和组织提供了新的见解，并有助于阐明其在正常维持和修复中的作用。用于肺上皮细胞分离和培养的新兴技术也为在受控系统中研究祖细胞亚群的行为和调控提供了机会。这些进展为开发新的策略来调节上皮细胞行为和在肺部疾病中实现组织修复提供了希望。
