AGTR1 as a therapeutic target in ER-positive and ERBB2-negative breast cancer cases.
作者信息
Ateeq Bushra, Tomlins Scott A, Chinnaiyan Arul M
出版信息
Cell Cycle. 2009 Dec;8(23):3794-5. doi: 10.4161/cc.8.23.9976.
Abstract
摘要
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AGTR1 as a therapeutic target in ER-positive and ERBB2-negative breast cancer cases.AGTR1作为雌激素受体阳性和人表皮生长因子受体2阴性乳腺癌病例的治疗靶点。
Cell Cycle. 2009 Dec;8(23):3794-5. doi: 10.4161/cc.8.23.9976.
2
AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist.AGTR1过表达定义了乳腺癌的一个亚群，并赋予对AGTR1拮抗剂氯沙坦的敏感性。
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AGTR1 promotes lymph node metastasis in breast cancer by upregulating CXCR4/SDF-1α and inducing cell migration and invasion.AGTR1通过上调CXCR4/SDF-1α并诱导细胞迁移和侵袭促进乳腺癌的淋巴结转移。
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本文引用的文献
1
AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist.AGTR1过表达定义了乳腺癌的一个亚群，并赋予对AGTR1拮抗剂氯沙坦的敏感性。
Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10284-9. doi: 10.1073/pnas.0900351106. Epub 2009 Jun 1.
2
Anti-cancer actions of a recombinant antibody (R6313/G2) against the angiotensin II AT1 receptor.一种重组抗体（R6313/G2）对血管紧张素II AT1受体的抗癌作用。
Endocr Relat Cancer. 2008 Mar;15(1):277-88. doi: 10.1677/ERC-07-0068.
3
CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells.CARMA3/Bcl10/MALT1 依赖性核因子-κB 激活介导非免疫细胞中血管紧张素 II 反应性炎症信号传导。
Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):139-44. doi: 10.1073/pnas.0601947103. Epub 2006 Nov 13.
4
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.血管紧张素 II 细胞信号传导：在心血管系统中的生理和病理作用
Am J Physiol Cell Physiol. 2007 Jan;292(1):C82-97. doi: 10.1152/ajpcell.00287.2006. Epub 2006 Jul 26.
5
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.前列腺癌中TMPRSS2与ETS转录因子基因的反复融合
Science. 2005 Oct 28;310(5748):644-8. doi: 10.1126/science.1117679.
6
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N Engl J Med. 2005 Oct 20;353(16):1673-84. doi: 10.1056/NEJMoa052122.
7
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer.HER2阳性乳腺癌辅助化疗后使用曲妥珠单抗。
N Engl J Med. 2005 Oct 20;353(16):1659-72. doi: 10.1056/NEJMoa052306.
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Functional expression of the angiotensin II type 1 receptor in human ovarian carcinoma cells and its blockade therapy resulting in suppression of tumor invasion, angiogenesis, and peritoneal dissemination.血管紧张素II 1型受体在人卵巢癌细胞中的功能性表达及其阻断治疗导致肿瘤侵袭、血管生成和腹膜播散受到抑制。
Clin Cancer Res. 2005 Apr 1;11(7):2686-94. doi: 10.1158/1078-0432.CCR-04-1946.
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Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity.替米沙坦作为具有选择性过氧化物酶体增殖物激活受体γ调节活性的独特血管紧张素II受体拮抗剂的鉴定。
Hypertension. 2004 May;43(5):993-1002. doi: 10.1161/01.HYP.0000123072.34629.57. Epub 2004 Mar 8.
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