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The challenge of HIV-1 genetic diversity: discordant CD4+ T-Cell count and viral load in an untreated patient infected with a subtype F strain.HIV-1基因多样性的挑战：一名感染F亚型毒株的未治疗患者CD4+ T细胞计数与病毒载量不一致的情况
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本文引用的文献

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First transmission of human immunodeficiency virus Type 1 by a cellular blood product after mandatory nucleic acid screening in Germany.德国实施强制性核酸筛查后，首例通过细胞血液制品传播1型人类免疫缺陷病毒。
Transfusion. 2009 Sep;49(9):1836-44. doi: 10.1111/j.1537-2995.2009.02203.x. Epub 2009 May 11.
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Human immunodeficiency virus type 1 (HIV-1) plasma load discrepancies between the Roche COBAS AMPLICOR HIV-1 MONITOR Version 1.5 and the Roche COBAS AmpliPrep/COBAS TaqMan HIV-1 assays.罗氏COBAS AMPLICOR HIV-1 MONITOR 1.5版与罗氏COBAS AmpliPrep/COBAS TaqMan HIV-1检测法之间1型人类免疫缺陷病毒（HIV-1）血浆载量差异
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Evaluation of the Roche Cobas TaqMan and Abbott RealTime extraction-quantification systems for HIV-1 subtypes.罗氏Cobas TaqMan和雅培实时提取定量系统对HIV-1亚型的评估。
J Acquir Immune Defic Syndr. 2007 Apr 15;44(5):500-5. doi: 10.1097/QAI.0b013e31803260df.
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Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004.2004年HIV-1基因亚型和重组体的全球及区域分布情况。
AIDS. 2006 Oct 24;20(16):W13-23. doi: 10.1097/01.aids.0000247564.73009.bc.
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Genetic characterization of diverse HIV-1 strains in an immigrant population living in New York City.纽约市移民群体中多种HIV-1毒株的基因特征分析。
J Acquir Immune Defic Syndr. 2006 Apr 1;41(4):399-404. doi: 10.1097/01.qai.0000200663.47838.f1.
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The first B/G intersubtype recombinant form of human immunodeficiency virus type 1 (HIV-1) identified in Germany was undetected or underquantitated by some commercial viral load assays.在德国发现的首个1型人类免疫缺陷病毒（HIV-1）的B/G亚型间重组形式，在一些商业病毒载量检测中未被检测到或定量不足。
J Med Virol. 2006 Mar;78(3):311-7. doi: 10.1002/jmv.20541.
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Impact of human immunodeficiency virus type 1 (HIV-1) genetic diversity on performance of four commercial viral load assays: LCx HIV RNA Quantitative, AMPLICOR HIV-1 MONITOR v1.5, VERSANT HIV-1 RNA 3.0, and NucliSens HIV-1 QT.1型人类免疫缺陷病毒（HIV-1）基因多样性对四种商用病毒载量检测方法性能的影响：LCx HIV RNA定量检测法、AMPLICOR HIV-1 MONITOR v1.5检测法、VERSANT HIV-1 RNA 3.0检测法和NucliSens HIV-1 QT检测法
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HIV-1 infection among injection and ex-injection drug users from Rio de Janeiro, Brazil: prevalence, estimated incidence and genetic diversity.巴西里约热内卢注射吸毒者和曾经注射吸毒者中的HIV-1感染：患病率、估计发病率及基因多样性
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Failure to detect a non-B HIV-1 subtype by the HIV-1 Amplicor Monitor test, version 1.5: a case of unexpected vertical transmission.
AIDS. 2003 Mar 28;17(5):781-2. doi: 10.1097/00002030-200303280-00027.

The challenge of HIV-1 genetic diversity: discordant CD4+ T-Cell count and viral load in an untreated patient infected with a subtype F strain.

作者信息

Bolivar Hector, Geffin Rebeca, Manzi Gabriel, Fischl Margaret A, Holzmayer Vera, Mak Wai-Bing, Abravaya Klara, Hackett John

出版信息

J Acquir Immune Defic Syndr. 2009 Dec;52(5):659-61. doi: 10.1097/QAI.0b013e3181b72539.

DOI:10.1097/QAI.0b013e3181b72539
PMID:19935211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9295325/
Abstract
摘要