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临床标本中 Abbott RealTime HBV 病毒载量检测试剂盒所针对的区域的序列保守性。

Sequence conservation of the region targeted by the Abbott RealTime HBV viral load assay in clinical specimens.

机构信息

Abbott Molecular, Des Plaines, Illinois, USA.

出版信息

J Clin Microbiol. 2013 Apr;51(4):1260-2. doi: 10.1128/JCM.03003-12. Epub 2013 Jan 23.

DOI:10.1128/JCM.03003-12
PMID:23345287
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3666792/
Abstract

The Abbott RealTime HBV assay targets the N-terminal region of the S gene. Here we analyzed the sequence variability of the assay target region from >2,100 clinical specimens. Thermodynamic modeling of the percentage of bound primer/probe at the assay annealing temperature was performed to assess the potential effect of sequence variability.

摘要

Abbott RealTime HBV 检测法针对 S 基因的 N 端区域。在这里，我们分析了 2100 多个临床标本中检测靶区域的序列变异性。通过对检测退火温度下结合引物/探针的百分比进行热力学建模，评估了序列变异性的潜在影响。

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