Ge Jiajia, Erickson Sarah J, Godavarty Anuradha
Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, 10555 West Flagler Street EC 2675, Miami, Florida 33174, USA.
Appl Opt. 2009 Nov 20;48(33):6408-16. doi: 10.1364/AO.48.006408.
Handheld-probe-based optical imagers are a popular approach toward breast imaging because of their potential portability and maximum patient comfort. A novel handheld-probe-based optical imager has been developed and its feasibility for three-dimensional fluorescence tomographic imaging demonstrated. Extensive tomography studies were performed on large slab phantoms (650 ml) to assess the performance limits of the handheld imager. Experiments were performed by using different target volumes (0.1-0.45 cm3), target depths (1-3 cm), and fluorescence (Indocyanine Green) absorption contrast ratios in a nonfluorescing (1:0) and constant fluorescing backgrounds (1000:1 to 5:1). The estimated sensitivity and specificity of the handheld imager are 43% and 95%, respectively.
基于手持探头的光学成像仪因其潜在的便携性和能为患者带来最大程度的舒适感，成为乳腺成像的一种常用方法。一种新型的基于手持探头的光学成像仪已被研发出来，并证明了其用于三维荧光断层成像的可行性。对大型平板体模（650毫升）进行了广泛的断层成像研究，以评估手持成像仪的性能极限。实验采用了不同的目标体积（0.1 - 0.45立方厘米）、目标深度（1 - 3厘米），以及在非荧光（1:0）和恒定荧光背景（1000:1至5:1）下的荧光（吲哚菁绿）吸收对比度。该手持成像仪的估计灵敏度和特异性分别为43%和95%。
