Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiao Min Xiang, 100730, Beijing, People's Republic of China.
Graefes Arch Clin Exp Ophthalmol. 2010 Mar;248(3):429-34. doi: 10.1007/s00417-009-1241-0. Epub 2009 Nov 25.
Recent research has suggested that structural significant damage in the optic nerve head (ONH) and retinal nerve fiber layer (RNFL) may precede visual field loss. Optical coherence tomography (OCT) has become an important tool which has contributed to earlier and more accurate diagnosis of glaucoma over the past decade. RTVue OCT was the first frequency-domain OCT (FD-OCT) device to offer comprehensive glaucoma analysis including an RNFL thickness map and optic disc morphology. The aim of this study was to evaluate and compare the performance of FD-OCT for the detection of early and advanced glaucoma from normal eyes.
This was a cross-sectional study consisting of 63 normal eyes, and 37 with early and 41 with advanced glaucoma. All patients underwent RNFL thickness and ONH parameter measurements on the RTVue OCT. Glaucoma variables obtained from RTVue OCT were compared between the groups. Discriminating power for early glaucoma detection was expressed by using the analyses of area under the receiver operating characteristic curves (AUCs).
All RNFL thickness and ONH parameters but disc area showed significant differences between the normal and the glaucoma groups, and the highest AUCs for RNFL thickness was average thickness (AUC = 0.816) and for ONH parameters was cup/disc vertical ratio (AUC = 0.782). They were the best parameters for discriminating normal from early glaucomatous eyes.
Frequency-domain OCT (RTVue OCT) may offer comprehensive analysis for RNFL thickness and ONH, which showed good diagnostic ability in distinguishing normal from glaucomatous eyes.
最近的研究表明，视神经头（ONH）和视网膜神经纤维层（RNFL）的结构显著损伤可能先于视野丧失。在过去的十年中，光学相干断层扫描（OCT）已成为一种重要的工具，有助于更早、更准确地诊断青光眼。RTVue OCT 是第一个提供全面青光眼分析的频域 OCT（FD-OCT）设备，包括 RNFL 厚度图和视盘形态。本研究旨在评估和比较 FD-OCT 检测早期和晚期青光眼的性能。
这是一项横断面研究，包括 63 只正常眼、37 只早期青光眼和 41 只晚期青光眼。所有患者均接受 RTVue OCT 的 RNFL 厚度和 ONH 参数测量。比较 RTVue OCT 获得的青光眼变量。使用受试者工作特征曲线下面积（AUC）分析评估早期青光眼检测的鉴别力。
所有 RNFL 厚度和 ONH 参数（除视盘面积外）在正常眼和青光眼组之间均有显著差异，RNFL 厚度的最高 AUC 为平均厚度（AUC = 0.816），ONH 参数为杯盘垂直比（AUC = 0.782）。它们是区分正常和早期青光眼眼的最佳参数。
频域 OCT（RTVue OCT）可提供 RNFL 厚度和 ONH 的全面分析，在区分正常眼和青光眼眼方面具有良好的诊断能力。
