Vizzeri G, Weinreb R N, Gonzalez-Garcia A O, Bowd C, Medeiros F A, Sample P A, Zangwill L M
Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.
Br J Ophthalmol. 2009 Jun;93(6):775-81. doi: 10.1136/bjo.2008.150698. Epub 2009 Mar 19.
BACKGROUND/AIMS: To evaluate spectral-domain (SD) optical coherence tomography (OCT) reproducibility and assess the agreement between SD-OCT and Time-Domain (TD) OCT retinal nerve fibre layer (RNFL) measurements.
Three Cirrus-SD-OCT scans and one Stratus-TD-OCT scan were obtained from Diagnostic Innovations in Glaucoma Study (DIGS) healthy participants and glaucoma patients on the same day. Repeatability was evaluated using Sw (within-subject standard deviation), CV (coefficient of variation) and ICC (intraclass correlation coefficient). Agreement was assessed using correlation and Bland-Altman plots.
16 healthy participants (32 eyes) and 39 patients (78 eyes) were included. SD-OCT reproducibility was excellent in both groups. The CV and ICC for Average RNFL thickness were 1.5% and 0.96, respectively, in healthy eyes and 1.6% and 0.98, respectively, in patient eyes. Correlations between RNFL parameters were strong, particularly for average RNFL thickness (R(2) = 0.92 in patient eyes). Bland-Altman plots showed good agreement between instruments, with better agreement for average RNFL thickness than for sectoral RNFL parameters (for example, at 90 microm average RNFL thickness, 95% limits of agreement were -13.1 to 0.9 for healthy eyes and -16.2 to -0.3 microm for patient eyes).
SD-OCT measurements were highly repeatable in healthy and patient eyes. Although the agreement between instruments was good, TD-OCT provided thicker RNFL measurements than SD-OCT. Measurements with these instruments should not be considered interchangeable.
背景/目的：评估频域（SD）光学相干断层扫描（OCT）的可重复性，并评估SD-OCT与时域（TD）OCT测量视网膜神经纤维层（RNFL）之间的一致性。
在同一天从青光眼诊断创新研究（DIGS）的健康参与者和青光眼患者中获取三次Cirrus-SD-OCT扫描和一次Stratus-TD-OCT扫描。使用Sw（受试者内标准差）、CV（变异系数）和ICC（组内相关系数）评估重复性。使用相关性和Bland-Altman图评估一致性。
纳入16名健康参与者（32只眼）和39名患者（78只眼）。两组中SD-OCT的可重复性均极佳。健康眼中平均RNFL厚度的CV和ICC分别为1.5%和0.96，患者眼中分别为1.6%和0.98。RNFL参数之间的相关性很强，尤其是平均RNFL厚度（患者眼中R(2)=0.92）。Bland-Altman图显示仪器之间一致性良好，平均RNFL厚度的一致性优于扇形RNFL参数（例如，平均RNFL厚度为90微米时，健康眼的一致性界限为-13.1至0.9，患者眼为-16.2至-0.3微米）。
SD-OCT测量在健康眼和患者眼中具有高度可重复性。尽管仪器之间的一致性良好，但TD-OCT测量的RNFL厚度比SD-OCT厚。这些仪器的测量结果不应被视为可互换的。
