Division of Radiation Oncology, Taipei City Hospital Ren Ai Branch, Taiwan, China.
World J Gastroenterol. 2009 Nov 28;15(44):5592-7. doi: 10.3748/wjg.15.5592.
To investigate the risk association and compare the onset age of hepatocellular carcinoma (HCC) patients in Taiwan with different genotypes of MDM2-SNP309.
We analyzed MDM2-SNP309 genotypes from 58 patients with HCC and 138 cancer-free healthy controls consecutively. Genotyping of MDM2-SNP309 was conducted by restriction fragment length polymorphism assay.
The proportion of homozygous MDM2-SNP309 genotype (G/G) in cases and cancer-free healthy controls was similar (17.2% vs 16.7%). Multivariate analysis showed that the risk of G/G genotype of MDM2-SNP309 vs wild-type T/T genotype in patients with HCC was not significant (OR = 1.265, 95% CI = 0.074-21.77) after adjustment for sex, hepatitis B or C virus infection, age, and cardiovascular disease/diabetes. Nevertheless, there was a trend that GG genotype of MDM2-SNP309 might increase the risk in HCC patients infected with hepatitis virus (OR = 2.568, 95% CI = 0.054-121.69). Besides, the homozygous MDM2-SNP309 genotype did not exhibit a significantly earlier age of onset for HCC.
Current data suggest that the association between MDM2-SNP309 GG genotype and HCC is not significant, while the risk may be enhanced in patients infected by hepatitis virus in Taiwan.
研究不同 MDM2-SNP309 基因型的台湾肝癌（HCC）患者的风险关联和发病年龄。
我们连续分析了 58 例 HCC 患者和 138 例无癌症健康对照者的 MDM2-SNP309 基因型。通过限制性片段长度多态性分析进行 MDM2-SNP309 基因分型。
病例和无癌症健康对照者中纯合 MDM2-SNP309 基因型（G/G）的比例相似（17.2%比 16.7%）。多变量分析显示，调整性别、乙型肝炎或丙型肝炎病毒感染、年龄和心血管疾病/糖尿病后，MDM2-SNP309 的 G/G 基因型与 HCC 患者野生型 T/T 基因型相比，发生 HCC 的风险无显著差异（OR=1.265，95%CI=0.074-21.77）。然而，存在 GG 基因型可能增加乙型肝炎病毒感染的 HCC 患者发病风险的趋势（OR=2.568，95%CI=0.054-121.69）。此外，MDM2-SNP309 的纯合子基因型并未使 HCC 的发病年龄明显提前。
目前的数据表明，MDM2-SNP309 GG 基因型与 HCC 之间的关联不显著，而在台湾，乙型肝炎病毒感染的患者中，这种风险可能会增加。
