Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, Paris, France.
J Infect Dis. 2010 Jan 1;201(1):15-9. doi: 10.1086/648611.
Human antimycobacterial immunity is a critical component of tuberculosis (TB) pathogenesis that is often used to infer the presence of TB infection. We report high heritability (>50%) for in vitro secretion of tumor necrosis factor alpha and interferon gamma (IFN-gamma), and the frequency of antigen-specific IFN-gamma(+)CD4(+) and IFN-gamma(+)CD8(+) cells in the response of whole blood to mycobacterial challenge. In principal component analysis, the first 3 components explain 78% of the overall variance consistent with the effect of pleiotropic regulatory genes of human antimycobacterial immunity. These results directly demonstrate the pivotal role played by host genetics in quantitative measures of antimycobacterial immunity underlying immune diagnosis of TB infection.
人类抗分枝杆菌免疫是结核病（TB）发病机制的一个关键组成部分，常用于推断 TB 感染的存在。我们报告了体外分泌肿瘤坏死因子α和干扰素γ（IFN-γ）的高遗传性（>50%），以及全血对分枝杆菌挑战反应中抗原特异性 IFN-γ（+）CD4（+）和 IFN-γ（+）CD8（+）细胞的频率。在主成分分析中，前 3 个成分解释了总方差的 78%，与人类抗分枝杆菌免疫的多效调节基因的影响一致。这些结果直接证明了宿主遗传学在定量测量抗分枝杆菌免疫方面在 TB 感染免疫诊断中的关键作用。
