Capodanno Davide, Tamburino Corrado
Cardiovascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy.
Recent Pat Drug Deliv Formul. 2010 Jan;4(1):18-22. doi: 10.2174/187221110789957264.
Ultrapure poly[bis(trifluoroethoxy)phosphazene] is a novel biocompatible, anti-inflammatory, antithrombogenic polymer which has the potential to cover stent devices without elution of a cell cycle inhibiting drug. The properties of polyphosphazene are likely to extend its use to a broad array of promising applications. This article reviews the features of the polymer and some recent patents related to use of poly[bis(trifluoroethoxy)phosphazene] in coating, its relevance as compared to other polymers, current evidence on pre-clinical and clinical performance, and future perspectives.
