New England Research Institutes, 9 Galen St., Watertown, MA 02472, USA.
Prev Med. 2010 Jan-Feb;50(1-2):19-25. doi: 10.1016/j.ypmed.2009.11.006. Epub 2009 Nov 24.
The objective of this study was to determine the relative contribution of modifiable risk factors (physical activity, smoking, and alcohol consumption) to inter-subject variation in erectile dysfunction (ED).
The Boston Area Community Health (BACH) Survey used a multistage stratified random sample to recruit 2301 men age 30-79 years from the city of Boston between 2002 and 2005. ED was assessed using the 5-item International Index of Erectile Function (IIEF-5). Multiple linear regression models and R(2) were used to determine the proportion of the variance explained by modifiable risk factors.
In unadjusted analyses, lifestyle factors accounted for 12.2% of the inter-subject variability in IIEF-5 scores, comparable to the proportion explained by comorbid conditions (14.7%) and socioeconomic status (9%). Lifestyle factors were also significantly associated with age, comorbid conditions and socioeconomic status (SES). A multivariate model including all covariates associated with ED explained 29% of the variance, with lifestyle factors accounting for 0.9% over and above all other covariates in the model. Analyses repeated in a subgroup of 1215 men without comorbid conditions show lifestyle factors accounting for 2.5% of the variance after accounting for all other variables in the model.
Results of the present study demonstrate the contribution of modifiable lifestyle factors to the prevalence of ED. These results suggest a role for behavior modification in the prevention of ED.
本研究旨在确定可改变的风险因素（体力活动、吸烟和饮酒）对勃起功能障碍（ED）个体间差异的相对贡献。
波士顿地区社区健康（BACH）调查采用多阶段分层随机抽样方法，于 2002 年至 2005 年在波士顿市招募了 2301 名 30-79 岁的男性。使用 5 项国际勃起功能指数（IIEF-5）评估 ED。采用多元线性回归模型和 R(2)来确定可改变的风险因素解释的方差比例。
在未调整的分析中，生活方式因素占 IIEF-5 评分个体间差异的 12.2%，与合并症（14.7%）和社会经济地位（9%）所解释的比例相当。生活方式因素也与年龄、合并症和社会经济地位显著相关。包括所有与 ED 相关的协变量的多元模型解释了 29%的方差，生活方式因素在模型中除其他所有协变量外，还额外解释了 0.9%的方差。在没有合并症的 1215 名男性亚组中的重复分析表明，在考虑模型中所有其他变量后，生活方式因素占方差的 2.5%。
本研究结果表明可改变的生活方式因素对 ED 的患病率有贡献。这些结果表明行为改变在 ED 的预防中具有作用。
