Department of Cardiology, Harvard Medical School, Brigham and Women's/Faulkner Hospitals, 1153 Centre Street, Boston, MA 02130, USA.
Clin Geriatr Med. 2009 Nov;25(4):591-606, vii. doi: 10.1016/j.cger.2009.08.001.
Older adults carry the highest risk for coronary artery disease and the highest burden of atherosclerosis. Although most clinical trials of cholesterol-lowering therapy have not specifically targeted older persons, growing evidence supports treatment of elevated low-density lipoprotein cholesterol levels in older patients, especially those at high risk for coronary events. The decision to treat a high or high-normal cholesterol level in an elderly individual must be individualized based on chronologic and physiologic age. This article summarizes current data on lipid-lowering therapy in older adults and the management of hyperlipidemia in elderly patients.
老年人患冠状动脉疾病的风险最高，动脉粥样硬化的负担也最大。虽然大多数降低胆固醇治疗的临床试验并未特别针对老年人，但越来越多的证据支持治疗老年患者的升高的低密度脂蛋白胆固醇水平，特别是那些有高冠状动脉事件风险的患者。在老年个体中治疗高或高正常胆固醇水平的决定必须根据实际年龄和生理年龄进行个体化。本文总结了目前关于老年人降脂治疗和老年患者高脂血症管理的相关数据。
