足月新生儿缺氧缺血性脑病。
Hypoxic-ischemic encephalopathy in the term infant.
机构信息
Kennedy Krieger Institute, Department of Neurology, Johns Hopkins Medical Institutions, 707 N Broadway, Baltimore, MD 21205, USA.
出版信息
Clin Perinatol. 2009 Dec;36(4):835-58, vii. doi: 10.1016/j.clp.2009.07.011.
Abstract
Hypoxia-ischemia in the perinatal period is an important cause of cerebral palsy and associated disabilities in children. There has been significant research progress in hypoxic-ischemic encephalopathy over the last 2 decades, and many new molecular mechanisms have been identified. Despite all these advances, therapeutic interventions are still limited. In this article the authors discuss several molecular pathways involved in hypoxia-ischemia, and potential therapeutic targets.
摘要
围产期缺氧缺血是导致脑瘫和儿童相关残疾的重要原因。在过去的 20 年里，缺氧缺血性脑病的研究取得了重大进展，许多新的分子机制已经被确定。尽管取得了所有这些进展，治疗干预仍然有限。本文作者讨论了缺氧缺血相关的几个分子途径和潜在的治疗靶点。
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