Eli Lilly and Company, US Medical Division, Lilly Corporate Center, Indianapolis, IN 46285, USA.
Psychiatr Clin North Am. 2009 Dec;32(4):853-61. doi: 10.1016/j.psc.2009.09.001.
People with schizophrenia and concurrent depressive symptoms have poorer long-term functional outcomes compared with the nondepressed. Their poorer quality of life, greater use of mental health services, and higher risk of involvement with law enforcement agencies underscore a need for special treatment interventions. Treatment of the nonpsychotic dimensions of schizophrenia is a critical part of recovery. In a 3-year study, the depressed cohort was significantly more likely than the nondepressed to use relapse-related mental health services (emergency psychiatric services, sessions with psychiatrists); to be a safety concern (violent, arrested, victimized, or suicidal); to have greater substance-related problems; and to report poorer life satisfaction, quality of life, mental functioning, family relationships, and medication adherence. Furthermore, changes in depressed status were associated with changes in functional outcomes.
与无抑郁症状的患者相比，同时患有精神分裂症和抑郁症状的患者的长期功能预后较差。他们的生活质量较差，更多地使用精神卫生服务，并且更有可能与执法机构发生关联，这突显了需要特殊的治疗干预措施。治疗精神分裂症的非精神病症状是康复的关键部分。在一项为期 3 年的研究中，与无抑郁症状的患者相比，抑郁组更有可能使用与复发相关的精神卫生服务（急诊精神科服务、与精神科医生的会谈）；存在安全隐患（暴力、被捕、受害或自杀）；存在更严重的物质相关问题；并且生活满意度、生活质量、心理功能、家庭关系和药物依从性更差。此外，抑郁状态的变化与功能预后的变化相关。
