Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Am J Otolaryngol. 2010 Jan-Feb;31(1):49-53. doi: 10.1016/j.amjoto.2008.08.009. Epub 2009 Mar 6.
Sensorineural hearing loss (SNHL) is a known complication of cryptococcal meningitis; however, it is unusual for a patient to present with isolated otologic symptoms. We review the case of a patient who is not immunocompromised and who presented with progressive gait instability and sudden onset of left-sided SNHL followed by progression to bilateral SNHL within a 3-week period. Cryptococcal meningitis was confirmed by lumbar puncture with positive cryptococcus antigen in the cerebrospinal fluid. The patient was treated with systemic antifungals, and the hearing loss persisted. The presented report outlines this patient's unusual presentation and his treatment course and reviews the literature on the otologic manifestations of cryptococcal meningitis.
感音神经性听力损失 (SNHL) 是隐球菌性脑膜炎的已知并发症；然而，患者出现孤立性耳科症状并不常见。我们回顾了一例无免疫功能低下的患者，该患者在 3 周内出现进行性步态不稳和突发性左侧 SNHL，随后进展为双侧 SNHL。隐球菌性脑膜炎通过腰椎穿刺确诊，脑脊液中存在阳性隐球菌抗原。该患者接受了全身抗真菌治疗，但听力损失仍持续存在。本报告概述了该患者的不常见表现及其治疗过程，并回顾了关于隐球菌性脑膜炎耳科表现的文献。
