炎症在调节血小板生成和功能中的作用：血小板和巨核细胞中的 Toll 样受体。
The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes.
机构信息
Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, 700 Albany St, W507, Boston, MA 02118, USA.
出版信息
Thromb Res. 2010 Mar;125(3):205-9. doi: 10.1016/j.thromres.2009.11.004. Epub 2009 Nov 27.
Abstract
Platelets have been extensively studied as hemostatic regulators, stopping uncontrolled flow of blood from an injured vessel and allowing for repair. However, multiple studies have shown that platelets can interact with bacterial proteins, particularly seen during sepsis and inflammation. Immune cells recognize pathogens through Toll-like Receptors (TLRs). These same receptors allow platelets to recognize bacterial proteins and regulate platelet immunity and function. This review examines the TLRs expressed on platelets and megakaryocytes and how these receptors affect the function of these cells. Through TLRs, platelets go beyond hemostatic regulation and play a pivotal role in inflammation and infection.
摘要
血小板作为止血调节剂已被广泛研究，可阻止受伤血管中血液的失控流动，并有助于修复。然而，多项研究表明，血小板可以与细菌蛋白相互作用，特别是在脓毒症和炎症期间。免疫细胞通过 Toll 样受体 (TLR) 识别病原体。这些相同的受体允许血小板识别细菌蛋白并调节血小板免疫和功能。这篇综述检查了血小板和巨核细胞上表达的 TLR ，以及这些受体如何影响这些细胞的功能。通过 TLR ，血小板超越止血调节，在炎症和感染中发挥关键作用。
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