Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, United States.
Curr Opin Cell Biol. 2010 Apr;22(2):169-76. doi: 10.1016/j.ceb.2009.10.007. Epub 2009 Nov 27.
The mammalian target of rapamycin (mTOR) is a master regulator of cell growth and division that responds to a variety of stimuli, including nutrient, energy, and growth factors. In the last years, a significant number of pieces have been added to the puzzle of how mTOR coordinates and executes its functions. Extensive research on mTOR has also uncovered a complex network of regulatory loops that impact the therapeutic approaches aimed at targeting mTOR.
哺乳动物雷帕霉素靶蛋白（mTOR）是细胞生长和分裂的主要调节因子，对各种刺激（包括营养、能量和生长因子）作出反应。在过去几年中，人们对 mTOR 如何协调和执行其功能有了更多的了解。对 mTOR 的广泛研究还揭示了一个复杂的调节环网络，这些调节环网络影响着靶向 mTOR 的治疗方法。
