迈向未来：对土拉弗朗西斯菌发病机制和疫苗开发的洞察。
Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development.
机构信息
Center for Biopreparedness and Infectious Disease, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226-0509, USA.
出版信息
Microbiol Mol Biol Rev. 2009 Dec;73(4):684-711. doi: 10.1128/MMBR.00028-09.
Abstract
Francisella tularensis is a facultative intracellular gram-negative pathogen and the etiological agent of the zoonotic disease tularemia. Recent advances in the field of Francisella genetics have led to a rapid increase in both the generation and subsequent characterization of mutant strains exhibiting altered growth and/or virulence characteristics within various model systems of infection. In this review, we summarize the major properties of several Francisella species, including F. tularensis and F. novicida, and provide an up-to-date synopsis of the genes necessary for pathogenesis by these organisms and the determinants that are currently being targeted for vaccine development.
摘要
土拉弗朗西斯菌是一种兼性细胞内革兰氏阴性病原体，也是人畜共患疾病土拉热的病原体。土拉弗朗西斯菌遗传学领域的最新进展导致在各种感染模型系统中，具有改变的生长和/或毒力特征的突变株的产生和随后的表征迅速增加。在这篇综述中，我们总结了几种弗朗西斯菌属物种的主要特性，包括土拉弗朗西斯菌和傅氏弗朗西斯菌，并提供了这些生物体致病所必需的基因以及当前用于疫苗开发的目标决定因素的最新概述。
相似文献
1
Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development.迈向未来：对土拉弗朗西斯菌发病机制和疫苗开发的洞察。
Microbiol Mol Biol Rev. 2009 Dec;73(4):684-711. doi: 10.1128/MMBR.00028-09.
2
TolC and EmrA1 contribute to multidrug resistance and modulation of host cell death.托利霉素（TolC）和 EmrA1 有助于多种药物耐药性，并调节宿主细胞死亡。
J Bacteriol. 2024 Sep 19;206(9):e0024624. doi: 10.1128/jb.00246-24. Epub 2024 Aug 28.
3
Contributions of TolC Orthologs to Schu S4 Multidrug Resistance, Modulation of Host Cell Responses, and Virulence.托尔克（TolC）同源物对施氏假单胞菌 S4 多药耐药性、宿主细胞反应调节和毒力的贡献。
Infect Immun. 2019 Mar 25;87(4). doi: 10.1128/IAI.00823-18. Print 2019 Apr.
4
Transcription Elongation Factor GreA Plays a Key Role in Cellular Invasion and Virulence of Francisella tularensis subsp. novicida.转录延伸因子 GreA 在土拉弗朗西斯菌亚种 novicida 的细胞侵袭和毒力中发挥关键作用。
Sci Rep. 2018 May 2;8(1):6895. doi: 10.1038/s41598-018-25271-5.
5
Aim2 and Nlrp3 Are Dispensable for Vaccine-Induced Immunity against Francisella tularensis Live Vaccine Strain.目的 2 和 Nlrp3 对于对抗弗朗西斯氏菌活疫苗株的疫苗诱导免疫是可有可无的。
Infect Immun. 2021 Jun 16;89(7):e0013421. doi: 10.1128/IAI.00134-21.
6
Comparative review of Francisella tularensis and Francisella novicida.土拉弗朗西斯菌和新凶手弗朗西斯菌的比较综述
Front Cell Infect Microbiol. 2014 Mar 13;4:35. doi: 10.3389/fcimb.2014.00035. eCollection 2014.
7
Evaluation of Francisella tularensis ΔpdpC as a candidate live attenuated vaccine against respiratory challenge by a virulent SCHU P9 strain of Francisella tularensis in a C57BL/6J mouse model.在C57BL/6J小鼠模型中，评估土拉弗朗西斯菌ΔpdpC作为候选减毒活疫苗，抵抗土拉弗朗西斯菌强毒株SCHU P9引起的呼吸道感染的效果。
Microbiol Immunol. 2018 Jan;62(1):24-33. doi: 10.1111/1348-0421.12555. Epub 2018 Jan 1.
8
Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strain.土拉热弗朗西斯菌活疫苗株中减毒嘌呤营养缺陷型菌株的构建与鉴定
Infect Immun. 2006 Aug;74(8):4452-61. doi: 10.1128/IAI.00666-06.
9
Francisella tularensis as a potential agent of bioterrorism?土拉弗朗西斯菌会成为生物恐怖主义的潜在媒介吗？
Expert Rev Anti Infect Ther. 2015 Feb;13(2):141-4. doi: 10.1586/14787210.2015.986463. Epub 2014 Nov 21.
10
Perforin- and granzyme-mediated cytotoxic effector functions are essential for protection against Francisella tularensis following vaccination by the defined F. tularensis subsp. novicida ΔfopC vaccine strain.穿孔素和颗粒酶介导的细胞毒性效应功能对于用定义明确的弗氏土拉弗朗西斯菌亚种 novicida ΔfopC 疫苗株接种后预防土拉弗朗西斯菌至关重要。
Infect Immun. 2012 Jun;80(6):2177-85. doi: 10.1128/IAI.00036-12. Epub 2012 Apr 9.
引用本文的文献
1
Characterization of Microbial Growth, Pathogen Presence, and Histamine Accumulation in Chilled Rainbow Trout and Mackerel Samples Collected from Romanian Markets.罗马尼亚市场采集的冷藏虹鳟鱼和鲭鱼样本中微生物生长、病原体存在情况及组胺积累的特征分析
Pathogens. 2025 Jun 11;14(6):580. doi: 10.3390/pathogens14060580.
2
Prosthetic joint infection as an unusual presentation of causing exposure of laboratory personnel.人工关节感染作为一种不寻常的表现，导致实验室人员暴露。
IDCases. 2025 Mar 4;39:e02195. doi: 10.1016/j.idcr.2025.e02195. eCollection 2025.
3
Breaking the cellular defense: the role of autophagy evasion in virulence.突破细胞防御：自噬逃避在毒力中的作用。
Front Cell Infect Microbiol. 2024 Dec 24;14:1523597. doi: 10.3389/fcimb.2024.1523597. eCollection 2024.
4
Development of Effective Medical Countermeasures Against the Main Biowarfare Agents: The Importance of Antibodies.针对主要生物战剂的有效医学应对措施的研发：抗体的重要性
Microorganisms. 2024 Dec 18;12(12):2622. doi: 10.3390/microorganisms12122622.
5
Genetic Homogeneity of subsp. Strains in Kazakhstan.哈萨克斯坦亚种菌株的遗传同质性。
Pathogens. 2024 Jul 12;13(7):581. doi: 10.3390/pathogens13070581.
6
The bacterial patterns suggesting the dynamic features of tick-associated microorganisms in hard ticks.提示硬蜱相关微生物动态特征的细菌模式。
BMC Microbiol. 2024 May 24;24(1):179. doi: 10.1186/s12866-024-03323-3.
7
Seroepidemiology of Human Tularemia-Systematic Review and Meta-analysis of Seroprevalence Studies.人类兔热病血清流行病学——血清阳性率研究的系统评价与荟萃分析
Open Forum Infect Dis. 2023 Dec 14;11(2):ofad636. doi: 10.1093/ofid/ofad636. eCollection 2024 Feb.
8
Modified activities of macrophages' deubiquitinating enzymes after infection.感染后巨噬细胞去泛素化酶活性的改变。
Front Immunol. 2023 Sep 29;14:1252827. doi: 10.3389/fimmu.2023.1252827. eCollection 2023.
9
Characterization of three genomes from Oklahoma, USA.来自美国俄克拉何马州的三个基因组的特征分析。
Access Microbiol. 2023 Jun 14;5(6):acmi000451. doi: 10.1099/acmi.0.000451. eCollection 2023.
10
Comparative evaluation of protective immunity against induced by subunit or adenovirus-vectored vaccines.诱导的保护性免疫的亚单位疫苗或腺病毒载体疫苗的比较评价。
Front Cell Infect Microbiol. 2023 May 25;13:1195314. doi: 10.3389/fcimb.2023.1195314. eCollection 2023.
本文引用的文献
1
Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity island mutant (DeltaiglB) induces protective immunity against homotypic and heterotypic challenge.用特定的土拉弗朗西斯菌新凶手亚种致病岛突变体（ΔiglB）进行疫苗接种可诱导针对同型和异型攻击的保护性免疫。
Vaccine. 2009 Sep 18;27(41):5554-61. doi: 10.1016/j.vaccine.2009.07.034. Epub 2009 Aug 3.
2
Contribution of citrulline ureidase to Francisella tularensis strain Schu S4 pathogenesis.瓜氨酸脲酶对土拉热弗朗西斯菌Schu S4菌株致病机制的作用。
J Bacteriol. 2009 Aug;191(15):4798-806. doi: 10.1128/JB.00212-09. Epub 2009 Jun 5.
3
Identification of genes contributing to the virulence of Francisella tularensis SCHU S4 in a mouse intradermal infection model.在小鼠皮内感染模型中鉴定有助于土拉弗朗西斯菌SCHU S4毒力的基因。
PLoS One. 2009;4(5):e5463. doi: 10.1371/journal.pone.0005463. Epub 2009 May 8.
4
Functional analyses of pilin-like proteins from Francisella tularensis: complementation of type IV pilus phenotypes in Neisseria gonorrhoeae.土拉弗朗西斯菌菌毛样蛋白的功能分析：淋病奈瑟菌IV型菌毛表型的互补作用
Microbiology (Reading). 2009 Aug;155(Pt 8):2546-2559. doi: 10.1099/mic.0.028183-0. Epub 2009 May 7.
5
Lethal pulmonary infection with Francisella novicida is associated with severe sepsis.新凶手弗朗西斯菌致死性肺部感染与严重脓毒症相关。
J Leukoc Biol. 2009 Sep;86(3):491-504. doi: 10.1189/jlb.1208728. Epub 2009 Apr 28.
6
Targeted gene disruption in Francisella tularensis by group II introns.通过 II 类内含子在土拉弗朗西斯菌中进行靶向基因敲除。
Methods. 2009 Nov;49(3):270-4. doi: 10.1016/j.ymeth.2009.04.011. Epub 2009 May 4.
7
Intracellular biology and virulence determinants of Francisella tularensis revealed by transcriptional profiling inside macrophages.巨噬细胞内转录谱揭示的土拉弗朗西斯菌的细胞内生物学及毒力决定因素
Cell Microbiol. 2009 Jul;11(7):1128-50. doi: 10.1111/j.1462-5822.2009.01316.x. Epub 2009 Mar 18.
8
A Francisella novicida pdpA mutant exhibits limited intracellular replication and remains associated with the lysosomal marker LAMP-1.新凶手弗朗西斯菌pdpA突变体表现出有限的细胞内复制能力，并仍与溶酶体标记物LAMP-1相关联。
Microbiology (Reading). 2009 May;155(Pt 5):1498-1504. doi: 10.1099/mic.0.025445-0. Epub 2009 Apr 16.
9
Characterization of the pathogenicity island protein PdpA and its role in the virulence of Francisella novicida.致病性岛蛋白PdpA的特性及其在新凶手弗朗西斯菌毒力中的作用。
Microbiology (Reading). 2009 May;155(Pt 5):1489-1497. doi: 10.1099/mic.0.025379-0. Epub 2009 Apr 16.
10
Characterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genes.对guaA和guaB基因存在缺失的经合理减毒的土拉弗朗西斯菌疫苗菌株的特性分析。
Vaccine. 2009 Apr 21;27(18):2426-36. doi: 10.1016/j.vaccine.2009.02.073. Epub 2009 Mar 3.
Zotero 插件